%0 Journal Article
%T 外周血CD8+T细胞对肝细胞癌术后预后的价值研究<br>Study on the Prognostic Value of Peripheral Blood CD8+T Cells in Hepatocellular Carcinoma after Curative Hepatectomy
%A 孙浩然
%A 曹泽鹏
%A 赵宝晨
%A 万得晨
%A 周大臣
%A 陈忠彪
%A 张彬
%J Advances in Clinical Medicine
%P 507-516
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.151069
%X 目的&#65306;外周免疫景观可能在肝细胞癌(HCC)的识别和控制中起关键作用。本研究旨在探讨外周血CD8+T细胞数量在预测肝细胞癌根治性肝切除术后预后中的价值。方法&#65306;选取2018年8月至2023年7月79例于我院行根治性肝切除术的初诊HCC患者作为研究对象&#65292;分析外周血CD8+T细胞数量对患者预后的预测价值。流式细胞术检测CD8+T细胞数量。结果&#65306;CD8+T细胞数量在早期复发和死亡患者中明显减少(<i>p</i> &lt; 0.050)。多因素<i>Cox</i>回归分析显示CD8+T细胞数量是术后预后的独立影响因素(<i>p</i> &lt; 0.050)。CD8+T细胞数量减少组的无复发生存期(RFS)和总生存期(OS)明显短于非减少组。结果经亚组分析证实。结论&#65306;外周血CD8+T细胞数量与HCC患者根治性肝切除术术后预后不良相关&#65292;可作为HCC患者术后新的预后指标。<br>Objective: The peripheral immune landscape may play a key role in determining hepatocellular carcinoma (HCC) recognition and control. This study aimed to examine the utility of peripheral blood CD8+T cells in predicting prognosis in HCC after curative hepatectomy. Methods: 79 newly diagnosed HCC patients from August 2018 to July 2023 were selected as research objects, we analyzed the prognostic value of peripheral blood CD8+T cells of HCC patients who underwent curative hepatectomy. The number of CD8+T cells was detected by flow cytometry. Results: The number of CD8+T cells was significantly decreased in patients who developed recurrence and death (all <i>p</i> &lt; 0.050). <i>Cox</i> regression demonstrated that the number of CD8+T cells was an independent indicator for poor prognosis after hepatectomy (both <i>p</i> &lt; 0.050). The recurrence-free survival (RFS) and overall survival (OS) in decrease group were significantly shorter than non-decrease group. The results were confirmed by the subgroup analysis. Conclusion: The number of CD8+T cells in peripheral blood is associated with dismal outcomes in HCC patients and can serve as a novel prognostic indicator for HCC patients after curative hepatectomy.
%K CD8+T细胞&#65292
%K 肝细胞癌&#65292
%K 肝切除术&#65292
%K 早期复发&#65292
%K 预后<br>CD8+T Cells
%K Hepatocellular Carcinoma
%K Hepatectomy
%K Early Recurrence
%K Prognosis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=105152