%0 Journal Article
%T Role of P-Gp in Treatment of Cancer
%A Venkata Sai Nithin Reddy Yendapalli
%A Kelley Williams
%A Terry Oroszi
%J Journal of Cancer Therapy
%P 1-17
%@ 2151-1942
%D 2025
%I Scientific Research Publishing
%R 10.4236/jct.2025.161001
%X P-glycoprotein (P-gp), a member of the ATP-binding cassette (ABC) family of transporters, plays a crucial role in the development of multi-drug resistance (MDR) in cancer treatment. P-gp actively pumps chemotherapeutic drugs out of cancer cells, reducing their intracellular concentrations and thereby diminishing their efficacy. This review explores the mechanisms by which P-gp contributes to MDR, including intrinsic and acquired resistance. It also discusses various strategies to inhibit P-gp, such as blocking drug binding sites, interfering with ATP hydrolysis, and altering cell membrane integrity. The potential of fourth-generation P-gp inhibitors and other novel approaches to enhance the effectiveness of cancer therapies is also examined. Understanding and overcoming P-gp-mediated MDR is essential for improving therapeutic outcomes in cancer patients.
%K P-Glycoprotein (P-Gp)
%K Multi-Drug Resistance (MDR)
%K Cancer Treatment
%K ABC Transporters
%K Chemotherapy Resistance
%K P-Gp Inhibitors
%K Drug Efflux Mechanisms Fourth-Generation Inhibitors
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=138708