%0 Journal Article
%T 探究一款后生元牙膏对口腔菌群的影响
Exploring the Impact of a Postbiotic Toothpaste on Oral Microbiota
%A 李颖甜
%A 张文瑾
%A 王梦雪
%A 黄正梅
%A 赵化冰
%J Advances in Microbiology
%P 267-276
%@ 2327-0829
%D 2024
%I Hans Publishing
%R 10.12677/amb.2024.134028
%X 目的：探究一款后生元牙膏对健康人群口腔菌群的影响。方法：纳入30名口腔健康人群，在使用牙膏前(0 d)和使用30天后(30 d)分别采集唾液，测定PLI值和CAT值，并进行16S rDNA测序，分析两组菌群结构及多样性差异。结果：与使用前相比，使用牙膏后的PLI值和CAT值均显著降低(P < 0.0001)。使用牙膏前后口腔菌群的优势菌基本一致，但在相对丰度上存在差异。与使用前相比，使用牙膏后的Alpha多样性指数Ace和Chao均显著降低(P < 0.0001)。PCA分析结果显示，使用牙膏前后的口腔菌群组成差异主要由嗜二氧化碳细胞菌属(Capnocytophaga)和孪生球菌属(Gemella)导致。结论：该款后生元牙膏能够有效减少牙菌斑，降低龋病风险，并能够调节口腔微生态。
Objective: To investigate the effect of a postbiotic toothpaste on the oral microbiota of healthy people. Methods: A total of 30 oral health individuals were enrolled, and saliva was collected before (0 day) and 30 days after 30 days (30 days) of toothpaste, and PLI and CAT values were measured, and 16S rDNA sequencing was performed to analyze the differences in microbial community structure and diversity between the two groups. Results: Compared with the before use, the PLI value and CAT value were significantly reduced after using toothpaste (P < 0.0001). The dominant bacteria in the oral microbiota were basically the same before and after the use of toothpaste, but there were differences in relative abundance. Compared with the before use, the alpha diversity index Ace and Chao were significantly decreased after using toothpaste (P < 0.0001). The results of PCA analysis showed that the differences in oral microbiota composition before and after toothpaste use were mainly caused by Capnocytophaga and Gemella. Conclusion: This postbiotic toothpaste can effectively reduce dental plaque, reduce the risk of caries, and regulate the oral microecology.
%K 后生元牙膏，
%K PLI，
%K CAT，
%K 16S rDNA测序技术，
%K 口腔菌群
Postbiotic Toothpaste
%K PLI
%K CAT
%K 16S rDNA Sequencing Technology
%K Oral Flora
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=104214