%0 Journal Article %T 药物联合rTMS对帕金森病临床症状及血清学指标改善的Meta分析
Meta Analysis of Drug Combination with rTMS for Improving Clinical Symptoms and Serological Indicators of Parkinson’s Disease %A 张赫 %A 何研娇 %J Journal of Clinical Personalized Medicine %P 2045-2057 %@ 2334-3443 %D 2024 %I Hans Publishing %R 10.12677/jcpm.2024.34289 %X 目的：针对药物联合rTMS治疗帕金森病的临床疗效进行文献Meta分析，为优化帕金森病治疗方案提供数据支持。方法：检索英文及中文数据库，收集rTMS联合药物治疗PD临床效果的相关文献，采集核心数据，进行Meta分析。结果：与单纯普拉克索组相比，rTMS联合普拉克索治疗PD后患者精神行为情绪[WMD = −0.37, 95% CI = (−0.47, −0.26)]，日常生活活动能力[WMD = −1.43, 95% CI = (−2.15, −0.70)]，运动功能[WMD = −2.13, 95% CI = (−2.74, −1.51)]，抑郁评分[WMD = −2.31, 95% CI = (−2.84, −1.78)]，简易智能精神状态[WMD = 2.23, 95%CI = (1.91, 2.54)]均得到改善，且两组间存在统计学差异(p < 0.05)。氧化应激反应指标均降低，Cys-C [WMD = −0.25, 95% CI = (−0.31, −0.19)]、NES [WMD = −2.75, 95% CI = (−3.50, −2.00)]、S100B [WMD = −4.88, 95% CI = (−6.03, −3.74)]，两组间存在统计学意义(p < 0.05)。与单纯多巴丝肼组相比，rTMS联合多巴丝肼治疗PD后患者精神行为情绪[WMD = −2.13, 95% CI = (−2.99, −1.27)]，日常生活活动能力[WMD = −6.11, 95% CI = (−7.05, −5.16)]，运动功能[WMD = −4.87, 95%CI = (−6.05, −3.69)]，自主神经症状[WMD = −6.85, 95% CI = (−7.96, −5.74)]均得到改善，且两组间存在统计学差异(p < 0.05)。神经递质水平得到改善，乙酰胆碱[WMD = −2.74, 95% CI = (−4.05, −1.44)]、多巴胺[WMD = 13.81, 95% CI = (11.02, 16.61)]，两组间存在统计学意义(p < 0.05)。结论：rTMS联合药物治疗可有效改善PD患者临床疗效，并对血清氧化应激及神经递质水平也存在调整作用。
Objective: To conduct a literature Meta-analysis on the clinical efficacy of drug combined with rTMS in the treatment of Parkinson’s disease, providing data support for optimizing the treatment plan of Parkinson’s disease. Method: Retrieve English and Chinese databases, collect relevant literature on the clinical efficacy of rTMS combined with drug therapy for PD, collect core data, and conduct Meta-analysis. Result: Compared with the Pramipexole alone group, patients with Parkinson’s disease treated with the combination of rTMS and Pramipexole had psychology, behavior and emotional [WMD = −0.37, 95% CI = (−0.47, −0.26)], activities of daily living [WMD = −1.43, 95% CI = (−2.15, −0.70)], motor function [WMD = −2.13, 95% CI = (−2.74, −1.51)], depression score [WMD = −2.31, 95% CI = (−2.84, −1.78)], and simplified mental state [WMD = 2.23, 95% CI = (1.91, 2.54)] showed varying degress of improvement, and there was a statistical difference between the two groups (p < 0.05). The oxidative stress response indicators were all reduced, with Cys-C [WMD = −0.25, 95% CI = (−0.31, −0.19)], NES %K 帕金森病， %K 多巴丝肼， %K 普拉克索， %K 重复经颅磁刺激， %K Meta分析
Parkinson’ %K s Disease %K Levodopa and Benserazide Hydochloride %K Pramipexole %K Repetitive Tranxcranial Magnetic Stimulation %K Meta-Analysis %U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=103274