%0 Journal Article
%T A New Process of Synthesizing Anandamide Derivatives from Arachidonic Acid in the Presence of Boron Catalyst
%A Mohammad Al-Masum
%A Linda Quinones
%J International Journal of Organic Chemistry
%P 128-134
%@ 2161-4695
%D 2024
%I Scientific Research Publishing
%R 10.4236/ijoc.2024.144008
%X Anandamide is part of the cannabinoid group and functions as a neurotransmitter. Anandamide plays a role in depression, pain, appetite, memory, and fertility. Since it is well documented that anandamide analog behaves as probes of the cannabinoid receptor, it is of great interest to find a new method of making new series of anandamide derivatives. Dennis Hall and his group recently reported a direct amidation process of carboxylic acid by ortho-iodo boronic acid. Using ortho-iodo boronic acid as a catalyst, we explore the amidation of arachidonic acid under microwave heating and synthesize anandamide derivatives in high yields.
%K Anandamide
%K Cross-Coupling
%K Microwave
%K Alcohol Amines
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=138338