%0 Journal Article
%T EGFR在肿瘤发生发展及治疗中的作用研究进展<br>Research Progress on the Role of EGFR in Tumorigenesis, Development and Treatment
%A 吕烨
%A 赵雅惠
%A 林佳
%J Advances in Clinical Medicine
%P 796-803
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.14123150
%X 表皮生长因子受体(Epidermal Growth Factor Receptor, EGFR)是一种关键的跨膜糖蛋白&#65292;广泛分布于人体各组织细胞膜上&#65292;其调控作用对于维持细胞的正常生理功能至关重要。科学研究表明&#65292;EGFR基因突变或表达水平异常升高可导致肿瘤的形成与扩散。自EGFR被发现以来&#65292;对其及其作用机制的研究已持续超过半个世纪&#65292;期间重大发现与突破不断涌现。本综述文章主要探讨了EGFR及其下游信号传导途径与肿瘤发生发展的关联&#65292;分析了以EGFR为靶点的肿瘤治疗药物&#65292;并对后续研究方向进行了客观的分析与展望。<br>The Epidermal Growth Factor Receptor (EGFR) is a key transmembrane glycoprotein that is widely distributed on cell membranes of various tissues in the human body. Its regulatory role is crucial to maintaining normal physiological functions of cells. Scientific research has shown that mutations or abnormally elevated expression levels of the EGFR gene can lead to the formation and spread of tumors. Since its discovery, research on EGFR and its mechanism of action has continued for more than half a century, during which major discoveries and breakthroughs have continued to emerge. This review article mainly discusses the relationship between EGFR and its downstream signal transduction pathways and tumor development, analyzes tumor therapeutic drugs targeting EGFR, and provides objective analysis and prospects for subsequent research directions.
%K EGFR&#65292
%K 信号通路&#65292
%K 肿瘤&#65292
%K EGFR靶向药物<br>EGFR
%K Signaling Pathway
%K Tumor
%K EGFR-Targeted Drugs
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=102999