%0 Journal Article
%T 2014~2023年全球国际高危克隆大肠埃希菌ST131的群体遗传特征研究<br>Global Population Genetic Characterisation of the International High Risk Clone <i>Escherichia coli</i> ST131, 2014~2023
%A 李静静
%J Advances in Clinical Medicine
%P 527-535
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.14123113
%X 背景&#65306;国际高危克隆大肠埃希菌(<i>Escherichia coli</i>) ST131是重要的医院获得性病原体&#65292;会导致尿路感染&#65292;血流感染以及呼吸道感染等&#65292;甚至死亡&#65292;给全球健康带来重大威胁。目的&#65306;探究ST131菌株的群体遗传特征&#65292;为控制大肠埃希菌抗生素耐药问题提供更多见解。结果&#65306;本研究收集2014~2023年来自全球的7735株ST131菌株全基因组测序数据&#65292;对其基因组特征进行了分析发现<i>sul</i>1 (54.6%)、<i>mph</i>(<i>A</i>) (53.3%)、<i>tet</i>(<i>A</i>) (52.5%)、<i>dfrA</i>17 (49.4%)、<i>sul</i>2 (38.4%)、<i>aph</i>(3<i>''</i>)<i>-</i><i>Ib</i> (38.0%)&#65292;<i>aph</i>(6)<i>-Id</i> (37.6%)&#65292;<i>bla</i><sub>TEM-</sub><sub>1</sub><sub>B</sub> (37.2%)&#65292;<i>bla</i><sub>CTX-M-</sub><sub>15</sub> (37.2%)是全球ST131菌株的优势磺胺类、大环内酯类、四环素类、甲氧苄啶类、氨基糖苷类、<i>&#946;</i>-内酰胺类抗生素耐药基因(ARGs)变体。<i>bla</i><sub>CTX-M-</sub><sub>27</sub>、<i>bla</i><sub>NDM-</sub><sub>5</sub>、<i>bla</i><sub>KPC-2</sub>、<i>bla</i><sub>KPC-3</sub>的检出率随时间呈升高趋势&#65307;而<i>aac</i>(3)<i>-</i><i>IId</i>、<i>aac</i>(6<i>'</i>)<i>-</i><i>Ib-cr</i>、<i>bla</i><sub>OXA-</sub><sub>1</sub>、<i>catB</i>3的检出呈下降趋势&#65307;同时<i>aadA</i>5、<i>aph</i>(3<i>''</i>)<i>-</i><i>Ib</i>、<i>a</i><i>ph</i>(6)<i>-Id</i>、<i>bla</i><sub>TEM-</sub><sub>1</sub><sub>B</sub>、<i>dfrA</i>17、<i>mph</i>(<i>A</i>)、<i>tet</i>(<i>A</i>)的检出呈波动变化(先升高再降低)。O25:H4是ST131的优势血清型。共检出543种毒力基因(VGs)&#65292;与菌株粘附、定植等功能有关。抗生素耐药基因(ARGs)和毒力基因(VGs)的数量随时间增加而增多(<i>P</i> &lt; 0.01)。结论&#65306;ST131大肠埃希菌在全球持续传播&#65292;菌株向着高耐药和高毒力的方向进化&#65292;正在对临床治疗造成重大威胁。<br>Background: The international high-risk clone <i>Escherichia coli</i> (ST131) is an important hospital-acquired pathogen that causes urinary tract infections, bloodstream infections, and respiratory infections, among other things, and even death, posing a major threat to global health. Objective: To explore the population genetic characteristics of ST131 strains and provide more insights into the problem of controlling antibiotic resistance in <i>Escherichia coli</i>. Results: In this study, we collected whole genome sequencing data of 7735 ST131 strains from around the world from 2014 to 2023 and analysed their genomic characteristics, found that <i>sul</i>1 (54.6%), <i>mph</i>(<i>A</i>) (53.3%), <i>tet</i>(<i>A</i>) (52.5%), <i>dfrA</i>17 (49.4%), <i>sul</i>2 (38.4%), <i>aph</i>(3<i>''</i>)<i>-</i><i>Ib</i> (38.0%), <i>aph</i>(6)<i>-Id</i> (37.6%), <i>bla</i><sub>TEM-</sub><sub>1</sub><sub>B</sub> (37.2%), <i>bla</i><sub>CTX-M-</sub><sub>15</sub> (37.2%) are the dominant antibiotic-resistant gene(ARGs) variants of sulfonamides, macrolides, tetracyclines, mephedrone, aminoglycosides, and <i>&#946;</i>-lactams for the global ST131 strain. <i>bla</i><sub>CTX-M-</sub><sub>27</sub>, <i>bla</i><sub>NDM-5</sub>,
%K 大肠埃希菌&#65292
%K ST131&#65292
%K 抗生素耐药基因(ARGs)&#65292
%K 毒力基因(VGs)<br><i>Escherichia coli</i>
%K ST131
%K Antibiotic Resistance Genes (ARGs)
%K Virulence Genes (VGs)
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=102786