%0 Journal Article
%T Physiological Variance of CD34 Marker’s Content in Twenty Tissues Determining Different Risks of Cardiovascular Diseases and Cancer in Them
%A Aleksey N. Shoutko
%A Marat A. Karamullin
%J Open Journal of Biophysics
%P 1-17
%@ 2164-5396
%D 2025
%I Scientific Research Publishing
%R 10.4236/ojbiphy.2025.151001
%X The decreasing of hazard ratio for cancer incidence (HR<sub>CVD</sub>) in the range of twenty native tissues (lung, liver, brain, hematologic, neuroendocrine renal, pancreas, lymphoid, bladder, colon, lip-oral-head-neck, leukocytic, rectum and anus, thyroid, soft tissue, prostate, skin, ovarian, breast, uterine) as much, as decreasing of the level of cardiovascular pathology (CVD) in the host before malignization, have been described by C.F. Bell <i>et al. </i>in 2023. Earlier, in 2022, the decreasing of 5-year mortality from cancer in similar range of tissues discussed by us as the inverse dependence from the content of stem CD34 markers in tissues before malignization, with example of population in England. In present article we investigate the interrelation between both data more thoroughly, using accessible and more representative populations level of the data. The analysis shows that high level of HR<sub>CVD </sub>is able to predicts only high cancer death for tissue sites in the beginning of the range, being applied to the referent data of cancer cases and deaths in estimated population of USA 2024. Along with this, an increasing the content of CD34 stem marker in the native tissues of the same range was favorite for increasing of cancer&#8217;s cases at the end of the range, diminishing, in parallel, the signs of vasculo-endothelial pathology, <i>i.e.</i> HR <sub>CVD</sub>. Thus, the cases (incidence) of cancer depend directly rather from content of CD34, which preexisted in native sites, than that from HR<sub>CVD</sub>. Further analysis shows that CD34 content averaged over twenty cites dominates over that CD2 marker of total T-cells more than 7 times, in oppose to their ratio in the blood. The enhancement of stem CD34 marker in the range of tissues is accompanied by unidirectional rising of its maturing derivatives, vasculo-endothelial CD31 and total T-cells CD2 markers, which contents relate positively to increasing of cancer death in US population 2024. The increase of CD34 decreases cancer mortality (death: cases) in sites, but indirectly, rather due to enhancement of the denominator. The high HR<sub>CVD</sub> (more than 1.0) in range of 20 tissues, concerns of those of them, which have had highest mitotic activity (by Ki67), but lowest &#8220;stemness&#8221; (by CD34), &#8220;vascularity&#8221; (by CD31), cancer&#8217;s incidence (cases) and the worse results of therapy. Oppositely, the normal tissue with lowest HR<sub>CVD</sub> (below 1.0) and Ki67, but highest CD34, CD31, and cancer incidence (cases) are more sensitive to treatment. Thus,
%K Population
%K Cardiovascular Pathology
%K Cancers
%K Interrelation
%K Tissues
%K CD Markers
%K Prognostic Value
%K Revision
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=137956