%0 Journal Article
%T Evaluation of Acute and Subacute Toxicities of a Recipe Based on Three Leafy Vegetables in Laboratory Rodents
%A Lewis Raud Miamb
%A Bonaventure Max Lazare Peneme
%A Berthrand St&#233
%A phane Lingomo Wossolo
%A Arnaud Wilfrid Etou Ossibi
%J Journal of Biosciences and Medicines
%P 67-78
%@ 2327-509X
%D 2024
%I Scientific Research Publishing
%R 10.4236/jbm.2024.1212006
%X The consumption of a mixture of leafy vegetables has always been a practice anchored in the dietary habits of the people of Brazzaville. The objective of this study was to evaluate the acute and subacute toxicities of the aqueous extract of the recipe based on three leafy vegetables (<i>Amaranthus hybridus</i> L., <i>Spinacia oleracea</i>, <i>Brassica campestris</i> L.) in laboratory rodents. The aqueous extract of the food recipe was administered orally using a cannula. Regarding acute toxicity, the administration of single doses of 5000 and 10,000 mg/kg to mice had no significant effects on behavior. On the other hand, weight loss was significantly (**p &lt; 0.01) compared to control mice (1 mL/100g). The results on subacute toxicity showed that daily administration of the aqueous extract of the food recipe at a dose of 1000 mg/kg for 21 days in rats resulted in a non-significant weight gain, and caused changes in some biochemical parameters including HDL-cholesterol levels, blood sugar levels and ALAT activity.
%K Leafy Vegetable
%K Food Recipe
%K Acute Toxicity
%K Subacute Toxicity
%K Biochemical Parameters
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=137902