%0 Journal Article
%T 分析231种饮食摄入与性早熟之间的因果关系&#8212;&#8212;一项双样本孟德尔随机化研究<br>Analyzing the Causal Relationship between 231 Dietary Intake and Precocious Puberty &#8212;A Two-Sample Mendelian Randomization Study
%A 陈薇
%A 张艳玲
%A 李静
%A 王秀锋
%J Advances in Clinical Medicine
%P 531-541
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.14112911
%X 目的&#65306;本文旨在将混杂因素的影响控制在最小的前提下&#65292;探讨特定的饮食摄入与性早熟(PP)发病的关系。方法&#65306;使用来自芬兰数据库(FinnGen)和英国生物样本库(UKB)的大规模全基因组关联研究(GWAS)汇总统计数据来探讨性早熟与231种饮食摄入之间的潜在关联。然后进行两样本孟德尔随机化(TSMR)分析&#65292;以进一步评估性早熟与饮食摄入之间的因果关系。结果&#65306;5种饮食摄入表现出正相关&#65292;即盐渍花生的摄入(ukb-b-1099) (OR = 1480.226, 95% CI = (14.460~151528.425), p = 0.002)、其他咸口小吃的摄入(ukb-b-18718) (OR = 326.312, 95% CI = (2.452~43431.149), p = 0.020)、西梅的摄入(ukb-b-3022) (OR = 1174.199, 95% CI = (6.603~208798.930), p = 0.007)、标准茶摄入量(ukb-b-3291) (OR = 1.011, 95% CI = (1.000~1.022), p = 0.040)及酒精摄入的频率(ukb-b-5799) (OR = 3.332, 95% CI = (1.491~7.448), p = 0.003)&#65307;其余4种表现出负相关&#65292;即白鱼的摄入(ukb-b-5427) (OR = 0.004, 95% CI = (0.000~0.259), p = 0.010)、牛奶布丁的摄入(ukb-b-9857) (OR = 0.002, 95% CI = (0.000~0.297), p = 0.015)、煎饼的摄入(ukb-b-6500) (OR = 0.014, 95% CI = (0.000~0.808), p = 0.039)、平均每周摄入烈酒(ukb-b-1707) (OR = 0.039, 95% CI = (0.002~0.624), p = 0.022)&#65307;此外&#65292;我们还发现性早熟与标准茶摄入量(ukb-b-3291) (OR = 0.402, 95% CI = (0.169~0.957), p = 0.04)、白鱼的摄入(ukb-b-5427) (OR = 0.998, 95% CI = (0.995~1.000), p = 0.038)存在反向因果关系。敏感性分析结果显示孟德尔随机化分析结果可靠。结论&#65306;盐渍花生、其他的咸口小吃、西梅、茶的摄入及酒精的摄入频率对性早熟存在致病效应&#65307;白鱼、牛奶布丁、煎饼的摄入及平均每周摄入烈酒与性早熟的延缓有关&#65307;患有性早熟可能会引起茶和白鱼的摄入量增加或减少。我们的研究结果为理解性早熟的发病机制提供了新的线索&#65292;重点关注会引起性早熟的饮食摄入&#65292;从而提供详细的饮食指导及干预&#65292;以期降低性早熟的发病率及年轻化趋势。<br>Objective: This study aims to investigate the relationship between specific dietary intakes and the onset of precocious puberty (PP) while minimizing the influence of confounding factors. Methods: Summary statistics from large-scale Genome-Wide Association Studies (GWAS) from the Finnish database (FinnGen) and the UK Biobank (UKB) were utilized to explore potential associations between precocious puberty and 231 types of dietary intakes. Two-sampled Mendelian Randomization (TSMR) analysis was subsequently conducted to further assess the causal relationship between precocious puberty and dietary intakes. Results: Five dietary intakes showed positive correlations: intake of salted peanuts (ukb-b-1099) (OR = 1480.226, 95% CI = (14.460~151528.425), p = 0.002), intake of other salty snacks (ukb-b-18718) (OR = 326.312, 95% CI = (2.452~43431.149), p = 0.020), intake of prunes (ukb-b-3022) (OR = 1174.199, 95% CI = (6.603~208798.930), p = 0.007), standard tea intake (ukb-b-3291) (OR = 1.011, 95% CI = (1.000~1.022), p = 0.040), and frequency of alcohol intake (ukb-b-5799) (OR = 3.332, 95% CI = (1.491~7.448), p = 0.003). The remaining four showed negative correlations: intake of white fish (ukb-b-5427) (OR = 0.004, 95% CI = (0.000~0.259), p = 0.010), intake of milk pudding (ukb-b-9857) (OR =
%K 饮食摄入&#65292
%K 性早熟&#65292
%K 孟德尔随机化<br>Dietary Intake
%K Precocious Puberty
%K Mendelian Randomization
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=99747