%0 Journal Article %T 中药单体治疗盆腔炎性疾病的研究进展
Research Progress of Traditional Chinese Medicine Monomer in the Treatment of Pelvic Inflammatory Disease %A 师雯迪 %A 周一 %A 沈文娟 %J Advances in Clinical Medicine %P 181-188 %@ 2161-8720 %D 2024 %I Hans Publishing %R 10.12677/acm.2024.14102637 %X 盆腔炎性疾病(PID)是育龄期女性的常见病和多发病，其发病率逐年呈上升趋势。临床上西药治疗有一定的局限性，对没有确定病原体的PID治疗效果不尽如人意，且长期使用抗生素会产生耐药菌，并使双重感染的风险大幅增加。然而，抑制疾病进展和缓解PID长期后遗症的新药需求尚未得到满足，中医药治疗因其副作用少，且治疗慢性病疗效明显而受到广泛关注。近年来，中医药在PID的治疗方面取得了明显进展，而中药单体是中草药中的活性成分，是新药开发的重要来源，为综述中药单体治疗PID的作用机制，本文总结了白芍总苷、金刚藤多糖、白藜芦醇、丹皮酚、连翘提取物、白头翁皂苷B4、菝葜总黄酮、芹菜素、菊苣酸、淫羊藿苷、柴胡皂苷A等在PID治疗过程中的关键环节，以期为临床PID的防治及新药研发提供参考依据和研究方向。
Pelvic inflammatory disease (PID) is a common and frequent disease in women of reproductive age, and its incidence is on the rise year by year. Clinical treatment with western drugs has limitations and is unsatisfactory for the treatment of PID without identified pathogens, and the long-term use of antibiotics produces drug-resistant organisms and dramatically increases the risk of double infections. However, there is an unmet need for new drugs to inhibit disease progression and alleviate the long-term sequelae of PID, and TCM treatment has received widespread attention because of its few side effects and its efficacy in treating chronic diseases. In recent years, TCM has made significant progress in the treatment of PID, and TCM monomers, the active ingredients in TCM, are an important source of new drug development. To review the mechanism of action of TCM monomers in the treatment of PID, this paper summarizes the role of Total glucosides of paeonyia, Smilax china L. polysaccharides, resveratrol, paeonol, forsythia suspensa extract, anemoside B4, total flavones of Smilax china L., apigenin, chicoric acid, and icariin, saikosaponin A and other key links in the treatment process of PID, with a view to providing a reference basis and research direction for the prevention and treatment of clinical PID and the development of new drugs. %K 盆腔炎性疾病， %K 中药单体， %K 白芍总苷， %K 金刚藤多糖， %K 白藜芦醇
Pelvic Inflammatory Disease %K Traditional Chinese Medicine Monomer %K Total Glucosides of Paeonyia %K Smilax china L. Polysaccharides %K Resveratrol %U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=97474