%0 Journal Article
%T New 4-imino-4<i>H</i>-Chromeno[2,3-<i>d</i>]Pyrimidin-3(5<i>H</i>)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and <i>in</i> <i>Silico</i> ADMET Properties
%A Marwa Dhiabi
%A Sirine Karoui
%A Mehdi Fakhfakh
%A Souhir Abid
%A Emmanuelle Limanton
%A R&#233
%A my Le Gu&#233
%A vel
%A Thierry Charlier
%A Ludovic Paquin
%A Jean-Pierre Bazureau
%A Houcine Ammar
%J International Journal of Organic Chemistry
%P 107-122
%@ 2161-4695
%D 2024
%I Scientific Research Publishing
%R 10.4236/ijoc.2024.143006
%X The synthesis of new 4-imino-4<i>H</i>-chromeno[2,3-<i>d</i>]pyrimidin-3(5<i>H</i>)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds <b>6c</b> showed micromolar cytotoxic activity on tumor cell lines (1.8 &lt; IC<sub>50</sub> &lt; 6 &#956;M) and no toxicity on fibroblasts (IC<sub>50</sub> &gt; 25 &#956;M). Finally, <i>in</i> <i>silico</i> ADMET studies ware performed to investigate the possibility of using of the identified compound <b>6c</b> as potential anti-tumor compound.
%K 2-Amino-4<i>H</i>-Chromene
%K 4<i>H</i>-Chromeno[2
%K 3-<i>d</i>]Pyrimidin-3(5<i>H</i>)-Amine
%K Microwave Irradiation
%K Tumoral Cell Line
%K <i>in</i> <i>Silico</i> ADMET
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=136244