%0 Journal Article
%T Identifying microRNA-Target Gene Pairs in Luminal B Breast Cancer Using Integrated Analysis of miRNA and Transcriptome Profiles
%A Kayalvili Ulaganathan
%A Raviteja Reddy Alipeddi
%A Surekha Rani Hanumanth
%J Advances in Breast Cancer Research
%P 69-100
%@ 2168-1597
%D 2024
%I Scientific Research Publishing
%R 10.4236/abcr.2024.134008
%X Dysregulation of post-transcriptional regulation of gene expression has been found to influence various human disorders. Aberrant miRNA-based regulation of gene expression has been found to be associated with different cancers, including breast cancers. Very little information is available on the effect of dysregulation of miRNA-mediated regulation on luminal B breast cancer. This study was aimed at comprehending the regulation of gene expression through miRNA in luminal B breast cancers by comprehensive analysis of miRNA and mRNA expression data together. Negatively regulated miRNA-target gene pairs were identified, and the target genes were functionally enriched to identify critical pathways associated with luminal B breast cancer. Further, the prognostic significance of these miRNAs and target gene pairs was assessed to identify genes with prognostic value in luminal B breast cancer. A total of 266 differentially expressed miRNAs and 164 dysregulated miRNA-target gene pairs were identified. Four genes, including SRP9, DSN1, RACGAP1, and SLC10A6, and one miRNA, hsa-mir-421, showed significant influence on the prognosis of patients with luminal B breast cancer. Through additional experimental examination of these findings, a deeper comprehension of miRNA-based post-transcriptional regulation in luminal B breast tumors will be possible.
%K Breast Cancer
%K Luminal B
%K miRNA
%K mRNA
%K TCGA
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=136137