%0 Journal Article
%T Antibacterial, Anti-Inflammatory and Antioxidant Activities of an ACAZY Herbal Formula Used in Traditional Medicine to Treat Respiratory Infections
%A Mohamed Bonewend&#233
%A Belemlilga
%A Bagora Bayala
%A Abdoul Gilchrist Laurent Boly
%A Madinatou Annick Ou&#233
%A draogo
%A Alida Raissa Boina
%A Boubacar Yaro
%A Florentina Badea
%A Cam&#233
%A lia Diguti
%A Moumouni Koala
%A Denise P. Ilboudo
%A Charles Bavouma Sombi&#233
%A Pascal Nadembega
%A Jean-Marie Compaor&#233
%A Paul Darga
%A Mahouk&#232
%A d&#232
%A Th&#233
%A odora Zohoncon
%A Moussa Ou&#233
%A draogo
%A Aristide Traore
%A Noufou Ou&#233
%A draogo
%A Florentina Matei
%A Rasmane Semd&#233
%A Sylvin Ou&#233
%A draogo
%A Jacques Simpor&#233
%A Innocent Pierre Guissou
%J Natural Science
%P 131-145
%@ 2150-4105
%D 2024
%I Scientific Research Publishing
%R 10.4236/ns.2024.169010
%X ACAZY is a plant formula used in traditional medicine in Burkina Faso to treat respiratory infections. After phytochemical analysis, this study evaluated extracts&#8217; anti-inflammatory, antioxidant and antibacterial properties from the ACAZY recipe. Three extractions, an aqueous macerate (AM), an aqueous decoction (AD) and an hydroethanolic macerate (HEM) of the ACAZY recipe powder were carried out. Phytochemical screening of the extracts was carried out using high-performance thin-layer chromatography (HPTLC) and the determination of phenolic compounds. The anti-inflammatory potential was assessed <i>in vitro </i>using pro-inflammatory enzyme inhibition tests. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and Ferric-reducing antioxidant power (FRAP) antioxidant properties were also determined. The antibacterial activity was evaluated on <i>Staphylococcus aureus</i> and <i>Streptococcus pneumoniae </i>strains. Phytochemical analysis revealed the presence of flavonoids, saponins, tannins, anthracenosids, sterols and triterpenes in the extracts. The extracts inhibited pro-inflammatory enzymes by more than 40% at only 100 &#181;g/mL. The extracts also showed potent antibacterial activity with a minimum inhibitory concentration 1 mg/mL on <i>Staphylococcus aureus</i> and 2 mg/mL on <i>Streptococcus pneumoniae</i>. The extracts in the ACAZY formula have shown anti-inflammatory and antioxidant properties <i>in vitro</i>. The AD also showed an antibacterial activity. This justifies its use in traditional medicine to treat acute respiratory infections.
%K ACAZY
%K Anti-Inflammatory
%K Antioxidant
%K Antibacterial
%K <i>In Vitro</i>
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=135859