%0 Journal Article %T Aβ状态调控ApoE ɛ4对MCI认知功能的影响
The Effect of Aβ Regulating ApoE ɛ4 on Cognitive Function in MCI %A 王希田 %A 巴茂文 %J Advances in Clinical Medicine %P 986-993 %@ 2161-8720 %D 2024 %I Hans Publishing %R 10.12677/acm.2024.1482311 %X 目的：探讨不同β淀粉样蛋白(β-amyloid, Aβ)状态调控ApoE ɛ4对轻度认知功能障碍(Mild Cognitive Impairment, MCI)患者的认知功能(cognitive function)的影响。材料与方法：选取阿尔茨海默病神经影像学计划(Alzheimer’s Disease Neuroimaging Initiative, ADNI)数据库中名421名MCI。收集他们的信息如性别、年龄、受教育年限、婚姻状况、18F-florbetapir-PET (用于检测脑内Aβ沉积的放射性检查)、脑脊液(cerebral spinal fluid, CSF) Aβ、CSF tau蛋白、CSF p-tau蛋白、神经心理学量表等。根据载脂蛋白E (Apolipoprotein E, ApoE)基因型将MCI患者分为ApoE ɛ4(+)组(n=202)和ApoE ɛ4(−)组(n = 219)，进一步根据Aβ状态分为Aβ(+)亚组和Aβ(−)亚组。通过统计学方法比较对应分组之间的差异，并分析引起差异的原因。结果：在MCI患者的ApoE ɛ4(+)和ApoE ɛ4(−)分组中，Aβ(+)亚组的年龄均显著大于Aβ(−)亚组，差异具有统计学意义(P < 0.001)；Aβ(+)亚组的CSF Aβ比Aβ(−)亚组低，CSF tau、p-tau比Aβ(−)亚组高，差异均具有统计学意义(P < 0.001)。ApoE ɛ4(+)组Aβ(+)亚组的多项神经心理学量表测评差于Aβ(−)亚组，尤其是在反映记忆功能量表方面，差异具有统计学意义(P < 0.05)。结论：Aβ与ApoE ɛ4的相互作用引起了MCI患者的认知功能下降，其中记忆功能的下降更为明显。
Objective: Exploring the effect of different β-amyloid (Aβ) regulating ApoE ɛ4 on cognitive function in patients with Mild Cognitive Impairment (MCI). Methods: We selected 421 MCI patients from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We collected their information, including gender, age, years of education, marital status, 18F-florbetapir-PET scan (a radiological test used to detect Aβ deposition in the brain), cerebrospinal fluid (CSF) Aβ, CSF tau protein, CSF p-tau protein, and neuropsychological test scores. Based on their Apolipoprotein E (ApoE) genotype, MCI patients were categorized into ApoE ε4(+) group (n = 202) and ApoE ε4(−) group (n = 219), further subdivided into Aβ(+) and Aβ(−) subgroups based on Aβ status. We compared the differences between corresponding groups using statistical methods and analyzed the factors contributing to these differences. Results: In the MCI patient groups with ApoE ε4(+) and ApoE ε4(−), the age of the Aβ(+) subgroup was significantly higher than that of the Aβ(−) subgroup, with the difference being statistically significant (P < 0.001); the CSF Aβ in the Aβ(+) subgroup was lower than those in %K 轻度认知功能障碍， %K 阿尔茨海默病神经影像学计划， %K ApoE ɛ %K 4， %K β %K 淀粉样蛋白， %K 认知功能
Mild Cognitive Impairment (MCI) %K Alzheimer’ %K s Disease Neuroimaging Initiative (ADNI) %K Apolipoprotein E ε %K 4 (ApoE ε %K 4) %K β %K Amyloid (Aβ %K ) %K Cognitive Function %U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=94740