%0 Journal Article
%T HRR、Cr/Cys-C在高血压合并冠心病的老年患者衰弱的研究进展<br>Research Progress of HRR, Cr/Cys-C in Elderly Feeble Patients with Hypertension Combined with Coronary Heart Disease
%A 康慧
%A 刘冀
%J Journal of Clinical Personalized Medicine
%P 354-362
%@ 2334-3443
%D 2024
%I Hans Publishing
%R 10.12677/jcpm.2024.32052
%X 衰弱是指机体多种系统功能异常或生理储备下降，导致易感性、易损性增加，抗应激能力减退的一种非特异性状态，致使衰弱老年人更易发生跌倒、残疾、感染甚至死亡等不良健康结局。在我国，心血管疾病是老年人常见的一类疾病，包括心脏和血管疾病，是引起死亡的主要疾病。由于高血压合并冠心病的老年患者衰弱的发生率高，预后差，故临床医师在接诊这部分特殊人群时，可对其进行衰弱评估表的初步筛查，有助于识别衰弱，从而制定更合理的诊疗计划，有助于改善老年人的健康状况。冠心病合并高血压的老年患者和衰弱的病理生理机制与炎性反应、氧化应激反应及激素代谢紊乱等因素相关。衰弱通常影响多个生理系统，冠心病合并高血压的老年衰弱患者更容易出现与此相关的不良预后(如跌倒、骨折、骨骼肌减少、残疾、认知障碍)，这导致了更高的住院率。目前国内外对冠心病合并高血压衰弱的研究逐渐重视。寻找合适的生物标志物对冠心病合并高血压衰弱进行早期诊断、病情监测和预后判断具有重要意义，本文旨在对HRR、Cr/Cys-C与高血压合并冠心病老年患者衰弱的研究进行综述。<br />
Frailty refers to a non-specific state in which the function of various systems of the body is abnormal or the physiological reserve is decreased, leading to the increase of susceptibility and vulnerability and the decrease of anti-stress ability, which makes the frailty elderly more prone to fall, disability, infection and even death and other adverse health outcomes. Cardiovascular disease is a common disease in the elderly in China, including heart and blood vessel disease, which is the main cause of death. Due to the high incidence of frailty in elderly patients with hypertension combined with coronary heart disease and poor prognosis, clinicians can conduct preliminary screening of frailty assessment form when receiving this part of the special population, which helps to identify frailty, so as to formulate a more reasonable diagnosis and treatment plan, and help to improve the health status of the elderly. The pathophysiological mechanism of frailty in elderly patients with coronary heart disease complicated with hypertension is related to inflammatory response, oxidative stress response and hormone metabolism disorder. Frailty often affects multiple physiological systems, and elderly frailty patients with coronary heart disease combined with hypertension are more likely to have associated poor outcomes (such as falls, fractures, sarcopenia, disability, cognitive impairment), which leads to higher rates of hospitalization. At present, more and more attention has been paid to the research of coronary heart disease combined with hypertension frailty. Finding suitable biomarkers is of great significance for early diagnosis, disease monitoring and prognosis judgment of coronary heart disease complicated with hypertension frailty. This paper aims to review the research on HRR, Cr/Cys-C and hypertension combined with coronary heart disease in elderly patients with frailty.
%K 衰弱，高血压，冠心病，外周血红蛋白与红细胞分布宽度比，肌酐与胱抑素C比<br>Frailty
%K Hypertension
%K Coronary Heart Disease
%K Ratio of Erythrocyte Distribution Width to Peripheral Blood Albumin (HRR)
%K Creatinine to Cystatin C (Cr/Cys-C)
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=88917