%0 Journal Article
%T 促炎性脂肪因子与2型糖尿病肾病的研究进展<br>Research Progress of Proinflammatory Adipokines and Type 2 Diabetic Nephropathy
%A 高丽萍
%A 秦凤
%J Journal of Clinical Personalized Medicine
%P 308-314
%@ 2334-3443
%D 2024
%I Hans Publishing
%R 10.12677/jcpm.2024.32045
%X 脂肪因子(adipokines)是由脂肪组织分泌的细胞家族，广泛参与机体糖、脂代谢的调节及血管内皮功能。随着人们生活水平的提高，肥胖在全球范围流行，促进了代谢相关疾病的发生，尤其是糖尿病(DM)在世界范围内快速发展，目前在我国主要以2型糖尿病(T2DM)为主，成为一种多发病和常见病，2型糖尿病微血管并发症是其致死致残的主要原因。T2DM发病关键环节是外周组织的胰岛素抵抗和胰岛B细胞功能缺陷。胰岛素抵抗可能是其发病的根本原因，而肥胖尤其是内脏脂肪肥胖与胰岛素抵抗密切相关。<br />
Adipokines, a family of cells secreted by adipose tissue, are widely involved in the regulation of glucose and lipid metabolism and vascular endothelial function. With the improvement of people’s living standards, obesity has become a global epidemic, which has promoted the occurrence of metabolic diseases, especially diabetes mellitus (DM) in the world, the rapid development of type 2 diabetes mellitus (T2DM) in China is mainly dominated by type 2 diabetes, which has become a kind of frequently-occurring and common disease, and microvascular complications of type 2 diabetes mellitus are the main cause of death and disability. The key links of T2DM pathogenesis are peripheral tissue insulin resistance and islet B cell dysfunction. Insulin resistance may be the root cause of its pathogenesis, and obesity, especially visceral fat obesity, is closely related to insulin resistance.
%K 脂肪因子，肥胖，糖尿病肾病，胰岛素抵抗<br>Adipokines
%K Obesity
%K Diabetic Nephropathy
%K Insulin Resistance
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=88910