%0 Journal Article
%T 放疗总疗程延长对恶性肿瘤的影响<br>The Impact of Prolonged Radiotherapy Duration on Malignant Tumors
%A 黄志凤
%A 张碧琳
%A 郭甜
%A 刘秋芳
%J Advances in Clinical Medicine
%P 958-965
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.1472101
%X 放射治疗在恶性肿瘤的治疗中的地位逐年增高，目前，大约近70%的肿瘤患者需要进行放射治疗。WHO公布的官方数据显示：45%的恶性肿瘤是可以治愈的，其中外科手术治疗占22%，放疗占18%，化疗占5%。但是在放射治疗过程中，有许多会影响治疗疗效的因素，除了与肿瘤相关的临床因素，放射治疗总疗程的长短也会对放射治疗疗效产生影响，其原因可能与肿瘤细胞的亚致死性损伤修复及加速再增殖有关，从而导致恶性肿瘤治疗后的局部区域失败和远处转移的发生。我们对放疗总疗程对各类恶性肿瘤的影响的文献进行了回顾，对放疗总疗程延长影响疗效的机制，影响疗程延长的原因，预防总疗程延长的措施及发生总疗程延长后的应对措施进行了汇总。<br />
Radiation therapy’s status in the treatment of malignant tumors has been rising steadily each year. Currently, approximately 70% of tumor patients require radiation therapy. According to official data released by WHO, 45% of malignant tumors can be cured, with surgical treatment accounting for 22%, radiation therapy for 18%, and chemotherapy for 5%. However, many factors can influence the efficacy of radiation therapy during the treatment process. In addition to tumor-related clinical factors, the duration of the total radiation therapy course can also affect its efficacy. This may be related to the repair of sublethal damage and accelerated repopulation of tumor cells, leading to local failure and distant metastasis after the treatment of malignant tumors. We have reviewed the literature on the impact of the total radiation therapy duration on various malignant tumors, summarized the mechanisms by which prolonged therapy duration affects efficacy, the reasons for therapy duration extension, preventive measures against prolonged therapy duration, and coping strategies when the total therapy duration is extended.
%K 放射治疗总疗程，恶性肿瘤，放疗疗效<br>Total Duration of Radiation Therapy
%K Malignant Tumors
%K Efficacy of Radiation Therapy
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=91914