%0 Journal Article
%T Ceritinib-Induced Organising Pneumonitis
%A Boon Hau Ng
%A Hsueh Jing Low
%A Nik Nuratiqah Nik Abeed
%A Nor Safiqah Sharil
%A Rose Azzlinda Osman
%A Mohd Imree Azmi
%A Marfuah Eezamuddeen
%A Andrea Yu-Lin Ban
%J Open Access Library Journal
%V 11
%N 9
%P 1-7
%@ 2333-9721
%D 2024
%I Open Access Library
%R 10.4236/oalib.1112075
%X Even though tyrosine kinase inhibitors (TKI) improve survival in non-small cell lung cancer (NSCLC), it is related to the risk of drug-induced pneumonitis. Whilst little is known regarding TKI-induced pneumonitis, adverse reactions carry a significant mortality rate and impact the available treatment options. Here, we present a case of an elderly gentleman diagnosed with metastatic ALK-positive NSCLC, who initially experienced ceritinib-induced skin vasculitis and subsequently developed acute respiratory distress syndrome upon being re-challenged with ceritinib. The patient¡¯s clinical and radiological condition showed improvement after initiating intravenous methylprednisolone and discontinuing the targeted therapy. Ceritinib-associated pneumonitis represents a rare form of pulmonary toxicity, emphasising the importance of early identification and intervention to mitigate mortality risk.
%K Ceritinib
%K Pneumonitis
%K Acute Respiratory Distress Syndrome
%K Corticosteroids
%U http://www.oalib.com/paper/6833894