%0 Journal Article
%T Genomic Profile of SARS-COV-2 Associated with COVID-19 Outbreaks in N’Djamena, Chad
%A Mathieu Hota
%A Henry Yandai Fissou
%A Dezoumbe Koutaya
%A Djallaye Djimto&#239
%A baye
%A Mahamat Moussa Ali
%J Advances in Bioscience and Biotechnology
%P 432-442
%@ 2156-8502
%D 2024
%I Scientific Research Publishing
%R 10.4236/abb.2024.157026
%X <b>Background:</b> SARS-CoV-2 has circulated worldwide with dramatic consequences. In Chad, we have no data reported of variants. The aim of this study was to identify the SARS-CoV-2 variants that circulated during the epidemic from 2020 to 2021. <b>Methods</b>: This is a cross-sectional, descriptive study carried out between 2020 and 2021. Samples from patients with suspected COVID-19 were tested in five laboratories in N&#8217;Djamena. One hundred quality samples of the positives were sequenced in Kinshasa using Oxford nanopore technologies minion and the Protocol Midnight SARS-CoV2. Data were processed using Excel version 16 software. <b>Results</b>: Of the 100 samples sequenced, 77 (77%) produced sequences, 23 (23%) did not. The genomic profiles were wild-type Wuhan and minor mutations (19A, 19B (A), 20A (B.1, B.2), 20B (AV.1), 20D (B.1.1.1 /C.36), 20C), variant of concern Alpha (20I), variant of concern Delta (21A/J), variant of interest Eta (21D), variant of concern Omicron (21K) and unclassified variant under surveillance (B.1.640). Of these variants, the maximums were detected in patients aged 26 - 35 with 30.26% and 25.26% in 36 - 45. However, 24.67% were in travelers and 75.32% in residents, 35.06% in those vaccinated against COVID-19 and 62.33% in non-vaccinates. The estimated case-fatality rate was 2.44% (107/4374). <b>Co</b><b>n</b><b>clusion:</b> This work has provided preliminary data on COVID-19 and SARS-CoV-2 variants circulating during the 2020-2021 epidemics in Chad.
%K COVID-19
%K SARS-CoV-2
%K Genomic Profile
%K Variant
%K Chad
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=134999