%0 Journal Article
%T 调节性T细胞介导的免疫逃逸在癌症中研究进展<br>Research Progress of Regulatory T Cell-Mediated Immune Escape in Cancer
%A 尹少宏
%J Advances in Clinical Medicine
%P 817-823
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.1461847
%X 多项研究显示调节性T (Treg)细胞在肿瘤细胞中的高浸润与癌症患者生存率低有关。所以确定Treg细胞中特异性表达并且影响Treg细胞稳态和功能的因子是非常重要的，这样可以了解癌症发病机制和确定治疗的靶点。因此，在肿瘤免疫治疗领域中，找到可以消耗Treg细胞并且控制Treg细胞功能从而去增强抗肿瘤免疫应答的方法是非常重要的。本文将回顾Treg细胞是怎样抑制抗肿瘤免疫应答，并讨论这些机制如何共同允许Treg细胞抑制抗肿瘤免疫应答。<br />
Multiple studies have shown that high infiltration of regulatory T (Treg) cells in tumor cells is associated with low survival in cancer patients. Therefore, it is very important to identify the factors that are specifically expressed in Treg cells and affect the homeostasis and function of Treg cells, so as to understand the pathogenesis of cancer and identify therapeutic targets. Therefore, in the field of tumor immunotherapy, it is very important to find ways to consume Treg cells and control Treg cell function to enhance anti-tumor immune response. This article reviews how Treg cells suppress the anti-tumor immune response and discusses how these mechanisms together allow Treg cells to suppress the anti-tumor immune response.
%K 调节性T细胞，免疫逃逸，抗肿瘤免疫应答<br>Regulatory T Cells
%K Immune Escape
%K Anti-Tumor Immune Response
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=89816