%0 Journal Article
%T Cytotoxic Properties on Cervical and Liver Cancer Cells of Two Plant Recipes from Burkina Faso
%A Estelle Ou&#233
%A draogo
%A Bagora Bayala
%A Th&#233
%A odora Mahouk&#232
%A d&#232
%A Zohoncon
%A Samiratou Ou&#233
%A draogo
%A Olga M&#233
%A lanie Lompo
%A Essi Etonam Dovo
%A Jean-Marie Compaor&#233
%A Albert Th&#233
%A ophane Yonli
%A Jacques Simpore
%J Journal of Biosciences and Medicines
%P 216-229
%@ 2327-509X
%D 2024
%I Scientific Research Publishing
%R 10.4236/jbm.2024.126019
%X Cancer is one of the deadliest diseases in developing countries. In recent years, natural plant-based compounds have been used in the search for drugs to combat numerous diseases, including cancer. In this study, we evaluate the cytotoxic properties of <i>paanfo tiben 1</i> and <i>paanfo tiben 2</i>, two traditional herbal formulations from Burkina Faso used in the treatment of cancer in Burkina Faso. To this end, the recipes were infused and freeze-dried. The dry extracts obtained were used to determine total phenolics and flavonoids content, assess antioxidant activity using the DPPH, ABTS and FRAP methods, evaluate anti-inflammatory properties by inhibiting 15-LOX, COX 1 and 2, and assess cytotoxic activity on HeLa cervical cancer and HePG2 liver cancer cell lines using the MTT test. The <i>paanfo tiben 1</i> recipe showed the highest levels of total phenolics and flavonoids, as well as the best antioxidant activities, with IC<sub>50</sub> values of 21.020 &#177; 0.6 &#181;g/ml and 22.94 &#177; 0.57 &#181;g/ml for DPPH and ABTS, and 165.15 mM EAA/mg dry extract for FRAP. It also exhibited the best cytotoxic activity with IC<sub>50</sub> values of 112.02 &#177; 0.025 &#181;g/ml on HeLa cells and 80.67 &#177; 6.08 &#181;g/ml on HepG2 cells. On the other hand, <i>paanfo tiben 2</i> exhibited the best anti-inflammatory activities through inhibition of 15-LOX and COX 1, with inhibition percentages at 100 &#181;g/ml of 32.523% and 24.717 % respectively. These results could justify the traditional use of these two recipes by traditional health practitioners in the treatment of cancer sufferers in Burkina Faso.
%K Antioxidant
%K Anti-Inflammatory
%K Cytotoxicity
%K <i>Paanfo Tiben</i>
%K Burkina
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=134004