%0 Journal Article
%T The Correlation between Free Triiodothyronine, Free Thyroxine and Hypertension in Depression Patients with Hypothyroidism and Its Clinical Guiding Value
%A Jingxuan Liu
%A Fang Wang
%A Xinhua Zhou
%J Journal of Biosciences and Medicines
%P 191-201
%@ 2327-509X
%D 2024
%I Scientific Research Publishing
%R 10.4236/jbm.2024.126017
%X Background: Cardiovascular diseases, such as hypertension and coronary heart disease, are often accompanied by thyroid and mental diseases, the harm of which poses great threats to patients&#8217; health. Objective: To explore the correlation between free triiodothyronine (FT<sub>3</sub>), free thyroxine (FT<sub>4</sub>) and hypertension in depression patients with hypothyroidism and its clinical guiding value. Methods: A total of 548 patients diagnosed with hypothyroidism in Wuxue First People&#8217;s Hospital of Hubei Province from January 2018 to September 2022 were enrolled. According to whether complicated with depression, they were divided into hypothyroidism without depression group (group A) and hypothyroidism with depression group (group B). The gender, age, comorbidities (such as depression, hypertension, diabetes, dyslipidemia, acute myocardial infarction), FT<sub>3</sub>, FT<sub>4</sub>, and thyroid stimulating hormone (TSH) levels were recorded. Spearman rank correlation was used to analyze hypertensive patients with hypothyroidism. Multivariate binary Logistic regression was used to analyze the influencing factors of hypertension in patients with hypothyroidism. Results: The TSH level, the number of hypertension, coronary heart disease and hyperlipidemia in group B were statistically significantly higher than those in group A (P < 0.05). The FT<sub>3</sub> level in group B was statistically significantly lower than that in group A (P < 0.05). Correlation analysis of hypertensive patients with hypothyroidism showed that hypertension was positively correlated with depression (r<sub>s</sub> = 0.092), coronary heart disease (r<sub>s</sub> = 0.000), hyperlipidemia (r<sub>s</sub> = 0.000), diabetes (r<sub>s</sub> = 0.000), and age (r<sub>s</sub> = 0.000), and negatively correlated with FT<sub>3</sub> (r<sub>s</sub> = 0.000) (P < 0.05). Logistic regression analysis showed that coronary heart disease, hyperlipidemia, FT<sub>3</sub> and FT<sub>4</sub> were the influencing factors of hypertension. The risk of hypertension in patients with coronary heart disease and hyperlipidemia significantly increased by 3.425 and 1.761 times (P < 0.01), respectively. With the decrease of FT<sub>3</sub>, the risk of hypertension increased (P < 0.01); With the increase of FT<sub>4</sub>, the risk of hypertension significantly increased (P < 0.01). Conclusions: Depression patients with hypothyroidism are more likely to suffer from hypertension, coronary heart disease and hyperlipidemia. Coronary heart disease and hyperlipidemia can increase the risk of hypertension
%K Hypothyroidism
%K Depression
%K Hypertension
%K Coronary Heart Disease
%K Correlation Analysis
%K FT<sub>3</sub>
%K FT<sub>4</sub>
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=134002