%0 Journal Article
%T 维生素D与结直肠癌的相关性及作用机制<br>Correlations and Mechanisms between Vitamin D and Colorectal Cancer
%A 赵为
%A 刘岚
%J Advances in Clinical Medicine
%P 443-452
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.1461794
%X 维生素D传统上被认为对体内钙和磷平衡有影响，但最近的证据强调了它对结直肠癌(Colorectal Cancer, CRC)的保护作用。本文综述了维生素D在预防结直肠癌中的作用，并探讨了维生素D对结直肠癌的影响机制。我们从PubMed和Web of Science中检索了维生素D在结直肠癌预防和治疗中的作用和机制。维生素D在结直肠癌的防治中发挥着越来越重要的作用，然而，维生素D适当剂量的选择是其在预防结直肠癌作用中有争议的部分。1<i>α</i>,25-二羟基维生素D3 [1,25(OH)2D3]通过多种信号通路发挥抗CRC作用，包括抑制增殖、诱导分化和凋亡、抑制转移和血管生成。此外，在肿瘤微环境(Tumor Microenvironment, TME)中，维生素D可以作用于CRC相关的间质成纤维细胞和CRC干细胞，发挥抗肿瘤作用。它还可以通过调节肠道微生物群，促进肿瘤抑制。维生素D对CRC的有效预防作用可以指导维生素D的合理使用，并为未来临床试验的合理设计和潜在机制的研究提供信息。<br />
While vitamin D is traditionally acknowledged of effects on homeostasis and phosphorus, recent evidence has highlighted its protective effect against colorectal cancer (CRC). The review investigates vitamin D function in CRC preventing and discusses mechanisms by which it affects CRC. Vitamin D role and mechanism in CRC prevention and therapy were searched from PubMed and Web of Science. Vitamin D plays an increasingly significant role in CRC prevention and treatment. However, its controversial role in CRC prevention depends, in part, on the selection of appropriate doses. 1<i>α</i>,25-dihydroxyvitamin D3 [1,25(OH)2D3] exhibits anti-CRC effects through various signalling pathways, involving suppressing proliferation, inducting differentiation and apoptosis, and inhibiting metastasis and angiogenesis. Moreover, within the tumour microenvironment (TME), vitamin D can act on CRC-associated stromal fibroblasts and CRC stem cells to exert antitumour effects. It may also regulate the gut microbiota to promote tumour repression. Vitamin D has beneficial preventive effects against colorectal cancer. These findings can guide vitamin D using appropriately and inform rational design of future clinical trials and research on the underlying mechanisms.
%K 维生素D，结直肠癌，预防，作用机制，肠道微生态<br>Vitamin D
%K Colorectal Cancer
%K Prevention
%K Mechanism of Action
%K Gut Microbiota
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=89233