%0 Journal Article
%T Detection of ARV-Resistant Mutants in HIV-1-Infected Individuals in a Context of Systematic Switching to an Association Based on Dolutegravir in Abidjan, Côte d’Ivoire
%A Odegue Kpadraux Danielle
%A Kakou-Ngazoa Solange
%A Dechi Jean-Jacques Renaud
%A Diallo Zelica
%A Sina Kouam&#233
%A Mireille
%A Sylla Aboubacar
%A Tossea Koui St&#233
%A phane
%A Kouakou Venance
%A Adagba Marius
%A Apia N&#8217
%A Chouo Kouam&#233
%A Basile
%A Tour&#233
%A Offianan Andr&#233
%A Dosso Mireille
%J American Journal of Molecular Biology
%P 138-151
%@ 2161-6663
%D 2024
%I Scientific Research Publishing
%R 10.4236/ajmb.2024.143011
%X The emergence of antiretroviral resistance mutations represents a major threat to the achievement of national and global goals for the elimination of HIV-1 infection. The global strategy in 2019 in C<span style=\"text-wrap:nowrap;\">&amp;#244;</span>te d'Ivoire is a new national policy for the management of people living with HIV with the administration of dolutegravir (DTG)-based fixed-dose combination. The aim of our study was to evaluate HIV-1 resistance to antiretrovirals (ARVs) in infected adult subjects in C<span style=\"text-wrap:nowrap;\">&amp;#244;</span>te d¡¯Ivoire in the context of a systematic switch to a DTG-based combination. Between February 2022 and October 2023, a cross-sectional survey with random sampling was conducted in 06 services caring for people living with HIV. A total of 139 participants were included in the study. Adults with a viral load ¡İ 1000 copies/mL were tested for HIV-1 ARV resistance mutations. Molecular analyses were performed using protocol of ANRS-MIE (National Agency for Research on AIDS and emerging infectious diseases). The interpretation is performed by HIVGRAD (<a href=\"https://www.hiv-grade.de/cms/grade/\" target=\"_blank\">https://www.hiv-grade.de/cms/grade/</a>).<span style=\"display:none;\" id=\"__kindeditor_bookmark_end_3__\"></span> The frequencies of HIV-1 resistance to non-nucleotide reverse transcriptase inhibitors (NNRTIs), nucleotide reverse transcriptase inhibitors (NRTIs), integrase inhibitors (IINTs) and protease inhibitors (PIs) were 82%, 73%, 19% and 11% respectively. The main mutations observed in the different classes were K103N (45%), M184V (64%), E157Q (19%) and L10V/M46I/A71V/I54V (6%) respectively. This study reveals the emergence of resistance to DTG-based fixed-dose combinations, favored by high rates of resistance to NRTIs and NNRTIs. This finding underlines the need for enhanced viral load monitoring and HIV-1 genotyping tests to guide the choice of NRTIs for combination therapy. In addition, monitoring for mutations to second-generation NRTIs is essential, given the scale-up of DTG-based regimens currently underway in C<span style=\"text-wrap:nowrap;\">&amp;#244;</span>te d¡¯Ivoire.
%K Resistant Mutants
%K Dolutegravir
%K HIV-1
%K Antiretrovirals
%K C&#244
%K te d&#8217
%K Ivoire
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=133806