%0 Journal Article
%T CK7在浆液性卵巢癌中的研究进展<br>Research Progress of CK7 in Serous Ovarian Cancer
%A 周珍珍
%A 郭桂兰
%J Journal of Clinical Personalized Medicine
%P 300-307
%@ 2334-3443
%D 2024
%I Hans Publishing
%R 10.12677/jcpm.2024.32044
%X 卵巢癌(Ovarian Cancer, OC)是常见的妇科恶性肿瘤之一。上皮性卵巢癌(Epithelial Ovarian Cancer, EOC)在所有卵巢癌中大约占90%，其致死率在妇科肿瘤中居首位。浆液性卵巢癌(Serous Ovarian Cancer, SOC)约占上皮性卵巢癌75%，严重危害着女性身心健康。随着肿瘤基因研究不断深入，大多数学者认为浆液性卵巢癌的发生是多因素综合作用的结果，与基因改变密切相关，因此基因已成为其诊疗的新焦点。CK是由20个相关多肽链组成的多基因家族，是上皮组织中间纤维蛋白的重要组成成分。CK7是一种偏碱性的II型低分子蛋白，相对分子质量约为54 kda，其编码基因定位于人类的第12号染色体上。CK7在恶性疾病鉴别诊断、肿瘤细胞的转移、浸润及亚型确定等方面有着重要价值。研究CK7可以帮助了解卵巢癌的起源部位和致癌特性，使CK7蛋白可能成为治疗浆液性卵巢癌的期望药物靶标，从而有效抑制肿瘤细胞增殖、转移，改善患者的预后，延长其生存期。本综述主要从卵巢癌与各种免疫组化因子的关系以及CK7的生物学特征、CK7与浆液性卵巢癌的关系等方面进行介绍，为浆液性卵巢癌的临床诊断、预后评估以及指导个体化治疗提供理论依据。<br />
Ovarian cancer (OC) is one of the most common gynecological malignancies. Epithelial ovarian cancer (EOC) accounts for approximately 90% of all ovarian cancers and is the leading cause of death among gynecological tumors. Serous ovarian cancer (SOC) accounts for about 75% of epithelial ovarian cancers, and seriously harms women’s physical and mental health. With the deepening of tumor gene research, most scholars believe that the occurrence of serous ovarian cancer is the result of multi-factor synthesis and closely related to gene change, so gene has become a new focus of its diagnosis and treatment. CK is a multigene family composed of 20 related polypeptide chains and is an important component of intermediate fibrin in epithelial tissue. CK7 is an alkaline type II low molecular protein with a relative molecular mass of about 54 kda, and its coding gene is located on human chromosome 12. CK7 plays an important role in the differential diagnosis of malignant diseases, metastasis, invasion and subtype determination of tumor cells. The study of CK7 can help to understand the origin site and carcinogenic properties of ovarian cancer, so that CK7 protein may become a desired drug target for the treatment of serous ovarian cancer, so as to effectively inhibit the proliferation and metastasis of tumor cells, improve the prognosis of patients and prolong their survival. This review mainly introduces the relationship between ovarian cancer and various immunohistochemical factors, the biological characteristics of CK7, and the relationship between CK7 and serous ovarian cancer, providing theoretical basis for clinical diagnosis, prognosis assessment and individualized treatment of serous ovarian cancer.
%K 卵巢癌，浆液性卵巢癌，免疫组化，CK7<br>Ovarian Cancer
%K Serous Ovarian Cancer
%K Immunohistochemistry
%K CK7
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=88881