%0 Journal Article
%T A Descriptive Study of Human Papilloma Virus in Esophageal Squamous Cell Carcinoma in Uganda Assessed by p16 Immunohistochemistry <br />
%A Mohamed Mohamud
%A Robert Lukande
%A Mohamed Kimwero
%J Open Access Library Journal
%V 11
%N 7
%P 1-11
%@ 2333-9721
%D 2024
%I Open Access Library
%R 10.4236/oalib.1111780
%X <strong>Background</strong>: Esophageal cancer is the eighth most common cancer and the sixth common cause of cancer deaths worldwide. p16 expression is associated with a better prognosis in esophageal squamous cell carcinoma (ESCC) in high risk regions. <strong>Methods</strong>: Formalin fixed paraffin embedded tissue blocks from 110 patients with a diagnosis of ESCC were tested for p16 immunohistochemistry. The analysis of the data was done using Stata version 17.0. The Chi square test and corresponding p-values were used to compare the positivity of p16 with the independent variables of the study. The level of significance was assessed at a 95% confidence interval with a p-value of less than or equal to 0.05. <strong>Results</strong>: 110 cases diagnosed with ESCC were analyzed. The mean age of patients from whom specimens were collected was 59 years (SD ¡À 11). Most of the samples were from males, 73 (66.4%), while females were 37 (33.6%). The majority of the specimens were of conventional histological type, 108 (98.2%). Moderately differentiated squamous cell carcinoma was the most common grade (48.2%), followed by poorly differentiated squamous cfoma (19.1%). p16 expression was higher in ¡Ý55 year olds compared to 45 - 54 and 35 - 44 age groups (25%, 13%, and 4%) respectively. Moderately differentiated squamous carcinoma constituted the majority of the samples that stained positive for p16 (54.8%), followed by poorly differentiated squamous cell carcinoma (31%), and well differentiated squamous cell carcinoma (14.2%). <strong>Conclusion</strong>: The prevalence of p16 expression in esophageal squamous cell carcinoma in our study was 38.2%. This study may help to bridge the gap in knowledge of p16 expression in ESCC in Uganda.
%K Esophageal Squamous Cell Carcinoma
%K Human Papilloma Virus
%K P16
%U http://www.oalib.com/paper/6828186