%0 Journal Article
%T 泽泻及其配方颗粒的HPLC指纹图谱研究<br>Study on HPLC Fingerprint of <i>Alisma </i><i>plantago-aquatica</i> Linn. and Its Formula Granules
%A 廖玉兰
%A 杨小松
%A 王祥培
%A 吴红梅
%J Pharmacy Information
%P 261-269
%@ 2160-4452
%D 2024
%I Hans Publishing
%R 10.12677/pi.2024.133031
%X 目的：建立泽泻药材及其配方颗粒的HPLC指纹图谱。方法：色谱柱为ACQUITY HPLC BEH C<sub>18</sub> (2.1 mm × 100 mm, 1.7 μm)，流动相为0.05%磷酸水溶液–乙腈，梯度洗脱，流速为0.1 mL/min；检测波长为210 nm；柱温为30℃；进样量为2 μL。建立泽泻及其配方颗粒指纹图谱，并采用中药色谱指纹图谱评价系统进行相似度分析。结果：20批泽泻药材及其配方颗粒的HPLC指纹图谱共确认13个共有峰，泽泻药材及配方颗粒指纹图谱相似度在0.502~0.989之间，两者化学成分存在一定差异。结论：建立了稳定、可行的泽泻药材及配方颗粒指纹图谱，可为泽泻药材及其配方颗粒质量与评价提供参考依据。<br />
Objective: To establish HPLC fingerprint of <i>Alisma plantago-aquatica</i> Linn. and its formula granules. Methods: The chromatography was performed on ACQUITY HPLC BEH C18 (2.1 mm × 100 mm, 1.7 μm) column with mobile phase consisting of 0.05% phosphoric acid aqueous solution acetonitrile and gradient elution at the flow rate of 0.1 mL/min. The detection wavelength was 210 nm. The column temperature was 30？C. The sample size was 2 μL. The fingerprint of <i>Alisma plantago-aquatica</i> Linn. and its formula granules was established, and the similarity analysis was carried out by the TCM chromatographic fingerprint evaluation system. Results: A total of 13 common peaks were identified by HPLC fingerprints of 20 batches of <i>Alisma plantago-aquatica</i> Linn. and its formula granules. The similarity of fingerprints of <i>Alisma plantago-aquatica</i> Linn. and formula granules ranged from 0.502 to 0.989, and there were certain differences in chemical components between them. Conclusion: A stable and feasible fingerprint of <i>Alisma plant</i><i>a</i><i>go-aquatica</i> Linn. and its formula granules was established, which can provide reference for the quality and evaluation of <i>Alisma plantago-aquatica</i> Linn. and its formula granules.
%K 泽泻，HPLC指纹图谱，配方颗粒<br><i>Alisma plantago-aquatica</i> Linn.
%K HPLC Fingerprint
%K Formula Granule
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=87767