%0 Journal Article
%T Correlation between TGF<i>β</i>1 Gene Polymorphism and Asthma in Baise, Guangxi Children
%A Fangxin Cao
%A Na Lin
%A Juntao Lin
%A Gai Yang
%A Xintong Wang
%J Journal of Biosciences and Medicines
%P 300-311
%@ 2327-509X
%D 2024
%I Scientific Research Publishing
%R 10.4236/jbm.2024.125023
%X <b>Objective: </b>This research was to study the correlation between the rs1800469, rs1800470, rs2241712, rs224171 and rs4803455 of TGF<i>β</i>1 gene and asthma in Baise, Guangxi children. This research also studied the relationship between serum concentration of TGF<i>β</i>1 and childhood asthma. <b>Method: </b>From June 2022 to December 2023, 121 children had physical examination in affiliated Hospital of Youjiang Medical University for Nationalities were selected as control group and 118 children suffered from asthma in affiliated Hospital of Youjiang Medical University for Nationalities during the same period were selected as asthma group. <b>Result:</b> There was no correlation between rs1800469, rs1800470, rs2241712, rs2241715, rs4803455 and asthma in Baise, Guangxi children. Linkage disequilibrium analysis showed that there were strong linkage disequilibrium among rs1800469, rs1800470, rs2241712, rs2241715 and rs4803455. Their haplotypes had no significant correlation with childhood asthma. The serum concentration of TGF<i>β</i>1 in asthma group was lower than that in control group (p < 0.01), which may be a risk factor for asthma. The serum concentration of TGF<i>β</i>1 had no significant relationship with the genotypes of rs1800469, rs1800470, rs2241712, rs2241715 and rs4803455.
%K TGF&lt
%K i&gt
%K &amp
%K #946
%K &lt
%K /i&gt
%K 1
%K Chilhood Asthma
%K SNP
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=133438