%0 Journal Article
%T MYBL2基因与妇科恶性肿瘤相关性的研究进展<br>Research Progress on the Association between the MYBL2 Gene and Gynecologic Malignancies
%A 王脉
%A 张旭东
%A 景佩缜
%A 韩睿文
%A 陈蕊
%J Advances in Clinical Medicine
%P 458-465
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.1451449
%X MYBL2是MYB转录因子家族成员之一，是介导细胞周期进程、细胞存活和分化的重要的调控因子。研究表明，MYBL2在多种恶性肿瘤中呈过度表达状态，且其蛋白表达水平与临床不良预后相关。MYBL2在基因表达调控中起关键作用，并参与了细胞凋亡、细胞衰老、肿瘤发生发展等过程。MYBL2及其下游转录网络的参与者可以用作预后或预测生物标志物，作为将来更具体的抗癌疗法的潜在治疗靶标。近年大量研究显示，女性生殖系统恶性肿瘤中存在典型的MYBL2基因过表达现象，并且发现MYBL2与妇科肿瘤的化疗耐药、免疫治疗及临床预后密切相关。本文将对MYBL2在妇科肿瘤领域的研究进展进行综述，为肿瘤治疗提供新的思路和方向。<br />
MYBL2 is a vital member of the MYB transcription factor family and plays a critical role in regulating cell cycle progression, survival and differentiation. Extensive research has revealed that MYBL2 is frequently overexpressed in various malignancies and its protein expression level is a reliable indicator of poor clinical prognosis. MYBL2 is an important regulator that controls gene expression and is involved in various biological processes such as apoptosis, senescence, tumorigenesis, and development. The components of MYBL2 and its downstream transcriptional network could offer potential therapeutic targets for specific anticancer therapies and predictive biomarkers in the future. Recent studies have demonstrated that the MYBL2 gene is often overexpressed in malignant tumors of the female reproductive system. Additionally, MYBL2 is closely associated with chemotherapy resistance, immunotherapy and clinical prognosis of gynecologic tumors. This comprehensive article reviews the research progress of MYBL2 in the field of gynecologic oncology and presents new ideas and directions for cancer treatment.
%K MYBL2，恶性肿瘤，预后，生物标志物<br>MYBL2
%K Malignancy
%K Prognosis
%K Biomarkers
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=86384