%0 Journal Article
%T Precocious Puberty in a 5-Year-Old Girl with a Giant Hypothalamic Hamartoma Discovered Perinatally: Case Report
%A Ghita Bourkadi
%A Sanae Habibi
%A Sana Abourazzak
%A Moustapha Hida
%J Open Journal of Endocrine and Metabolic Diseases
%P 101-106
%@ 2165-7432
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojemd.2024.144012
%X <b>Background:</b> Hypothalamic hamartoma is a rare non-neoplastic lesion, typically identified in early childhood during investigations for precocious puberty and/or gelastic seizures. However, cases of diagnosis even earlier or during fetal development have been documented. <b>Case </b><b>Presentation</b><b>:</b> A newborn girl was diagnosed with hydrocephalus during pregnancy. An MRI revealed a large oval hypothalamic process, which suggested a hypothalamic hamartoma. At the age of 2, she experienced alternating crying and laughing seizures, followed by a decrease in visual acuity. Due to involvement of the optic pathways, surgery was not performed and she underwent antiepileptic medicines and gamma knife radiotherapy. At the age of 5 years and 3 months, she presented with breast development and laboratory tests confirmed central precocious puberty. Quarterly injections of GnRH agonists have since been administered with favorable results. <b>Conclusion:</b> Early-diagnosed hypothalamic hamartomas require close monitoring, by an experienced multidisciplinary, to promptly detect and treat potential complications, especially precocious puberty, and prevent any undesirable impact on final height.
%K Perinatally-Hypothalamic Hamartoma-Giant-Precocious Puberty
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=132752