%0 Journal Article
%T 五酯胶囊协同他克莫司治疗儿童激素耐药型肾病综合征的研究现状<br>The Current Status of Research on Wuzhi Capsules Associated with Tacrolimus for the Treatment of Pediatric Steroid-Resistant Nephrotic Syndrome
%A 陈家欢
%A 杨雪钧
%A 阳海平
%J Advances in Clinical Medicine
%P 2340-2345
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.1441300
%X 激素耐药型肾病综合征(Steroid-resistant nephrotic syndrome, SRNS)治疗难度大、周期长、预后相对较差。他克莫司是儿童SRNS最常用的免疫抑制剂，但存在药代动力学个体差异大、治疗窗窄及需要定期监测血药浓度的缺点。五酯胶囊在早期临床中多联合用药以减少药物性肝损害的发生。但在随访过程中逐渐发现协同用药可以提高他克莫司的血药浓度，进而降低他克莫司的用药剂量，减轻他克莫司的不良反应。本文就五酯胶囊协同他克莫司治疗儿童SRNS的研究现状进行综述。<br />
Steroid-resistant nephrotic syndrome is difficult to treat, has a long cycle, and has a poor prognosis. Tacrolimus is the most commonly used immunosuppressant for SRNS in Pediatric patients, but has the disadvantages of large individual differences in pharmacokinetics, a narrow therapeutic window and the need for regular monitoring of blood levels. Wuzhi capsules are mostly co-administered in early clinical practice to reduce the occurrence of drug-related liver damage. However, during the follow-up process, it was gradually found that the co-administration could increase the blood concentration of tacrolimus, which in turn reduced the dose of tacrolimus and reduced the adverse effects of tacrolimus. This article provides a review of the current state of research on Wuzhi capsules in combination with tacrolimus for the treatment of SRNS in children. We review the current status of research on pentothal capsules in co-administration with tacrolimus for the treatment of SRNS in children.
%K 激素耐药型肾病综合征，儿童，他克莫司，五酯胶囊<br>Steroid-Resistant Nephrotic Syndrome
%K Children
%K Tacrolimus
%K Wuzhi Capsules
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=85581