%0 Journal Article
%T 肝细胞癌根治性切除术后无复发生存时间和总生存的影响因素分析<br>An Analysis of the Factors Influencing Disease-Free and Overall Survival Time after Curative Resection for Hepatocellular Carcinoma
%A 陈琪栋
%A 梁军波
%J Advances in Clinical Medicine
%P 2267-2277
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.1441291
%X 目的：本研究的目的是调查影响接受根治性切除术的肝细胞癌(HCC)患者无病生存期(RFS)和总生存期(OS)的重要血清因子。患者和方法：从2011年到2018年，我们中心招募了187名接受肝癌根治性手术的患者。使用Kaplan-Meier方法生成生存曲线，并使用对数秩检验进行比较。使用单变量和多变量Cox比例风险模型评估RFS和OS的预后因素。结果：单因素和多变量分析表明，前白蛋白(PAB) (p = 0.016)和GGT (p = 0.007)与RFS独立相关，GGT (p = 0.039)、GGT/PAB (p = 0.038)和GGT/AST (p = 0.035)与OS独立相关。结论：根治性手术后原发性肝细胞癌的预后受多种因素影响。血清GGT、PAB、GGT/PAB和GGT/AST水平可作为评估术后患者预后的方便且经济的方法。<br />
Objective: The aim of the current study was to investigate the significant serum factors that influence recurrence-free survival (RFS) and overall survival (OS) in hepatocellular carcinoma (HCC) patients who receive curative resection. Patients and Methods: From 2011 to 2018, 187 patients who underwent radical surgery for HCC in our center were recruited. Survival curves were generated using the Kaplan-Meier method and compared using a log-rank test. The prognostic factors of RFS and OS were assessed using univariate and multivariable Cox proportional hazards models. Results: The univariate and multivariable analyses demonstrated that prealbumin (PAB) (p = 0.016) and GGT (p = 0.007) were independently associated with RFS, GGT (p = 0.039), GGT/PAB (p = 0.038) and GGT/AST (p = 0.035) were independently associated with OS. Conclusion: The prognosis of primary HCC after curative surgery can be influenced by many factors. Serum levels of GGT, PAB, GGT/PAB and GGT/AST might be used as convenient and economical methods for evaluating the prognosis of patients after surgery.
%K 肝癌，GGT，PAB，预后因素，根治性切除术<br>Hepatocellular Carcinoma
%K GGT
%K PAB
%K Prognostic Factor
%K Curative Resection
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=85572