%0 Journal Article
%T 抑郁症与应激、炎症和胰岛素抵抗之间关系的研究进展<br>Research Progress on the Relationship between Stress, Inflammation, Insulin Resistance and Depression
%A 谢克来·雪合热提
%A 胡红星
%J Advances in Clinical Medicine
%P 588-594
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.1441064
%X 抑郁症是一种危害全球人类生活质量的精神疾病，具有高患病率、高疾病负担、高致残率等特点。至今为止抑郁症的具体病理生理机制尚未明确，但抑郁症的炎症与生活事件导致的应激机制已被大众认可，近年来研究发现抑郁症与胰岛素抵抗存在高共患病率，胰岛素抵抗通过各种病理生理机制参与抑郁症的发生与发展，并有望成为新的抗抑郁治疗靶点。本文通过回顾近期国内外已发表的文献，总结了当前抑郁症与炎症、应激、胰岛素抵抗的相关性研究进展，并就胰岛素抵抗、炎症和应激三种因素相互之间可能存在的联系进行综述，为今后深入研究抑郁症机制和治疗方法提供思路和方向，为建设全民健康预防抑郁症提供新角度。<br />
Depression is a mental illness that endangers the quality of human life around the world, with high prevalence, high disease burden, and high disability rate. So far, the specific pathophysiological mechanism of depression has not been fully understood, but the mechanism of inflammation and the stress caused by life events in depression has been widely recognized. In recent years, studies have found that there is a high comorbid rate between depression and insulin resistance, and insulin resistance is involved in the occurrence and development of depression through various pathophysiological mechanisms, and is expected to become a new target for antidepressant treatment. This article summarizes the current research progress on the correlation between inflammation, stress, insulin resistance and depression and the possible relationship between the three factors by reviewing the recent published literature at inland and abroad, so as to provide ideas and directions for in-depth research on the mechanism and treatment of depression in the future, and provide a new perspective for the construction of national health to prevent depression.
%K 抑郁症，胰岛素抵抗，炎症，应激<br>Depression
%K Insulin Resistance
%K Inflammation
%K Stress
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=84306