%0 Journal Article
%T Predictive Factors of Renal Failure in COVID-19 Patients at the Anti-COVID Center in Lome, Togo
%A Kossi Akomola Sabi
%A Yoan Makafui Amekoudi
%A Aw&#233
%A r&#233
%A ou Kotosso
%A Laune Odilon Blatome
%A Badomta Dolaama
%A Ayod&#233
%A l&#233
%A Jonathan Sabi
%A Oscar Gnirimi Gbahbang
%A Loutou Ahoub-Laye Affo
%A B&#233
%A fa Noto-Kadou-Kaza
%J Open Journal of Nephrology
%P 125-135
%@ 2164-2869
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojneph.2024.142013
%X <b>Background</b><b>:</b><b> </b>Angiotensin-converting enzyme 2 has been identified as the receptor that allows the entry of SarsCov2 into the human cell. Its expression in the kidney is 100 times higher than in the lung; thus, making the kidney an excellent target for SarsCov2 infection manifesting as renal failure (RF). The objective of this study was to determine the predictive factors of RF during COVID-19 in the Togolese context. <b>Patients</b><b> </b><b>and</b><b> </b><b>Methods:</b><b> </b>This was a retrospective descriptive and analytical study conducted at the Lom¨¦ Anti-COVID Center including the records of patients hospitalized for COVID-19, of age ¡İ 18 years and having performed a creatinemia. RF was defined by a GFR &lt; 60 ml/min/1.73m<sup>2</sup> calculated according to the MDRD formula. Patients were randomized into 2 groups according to GFR&lt;60 or not. Statistical tests used were Pearson¡¯s Chi-2 test or Fisher¡¯s exact test for qualitative variables and Mann-Whitney test or Wilcoxon test for quantitative variables. The significance level was set at 0.05. Univariate and multivariate logistic regression was performed to search for associated factors. <b>Results</b><b>:</b> 482 patients were selected for this study with a mean age of 58.02 years. Sixty-five percent of the patients were men, <i>i.e.</i>, a sex ratio of 1.88. Fifty-two patients had RF, <i>i.e.</i>, a frequency of 10.8%.There were 65% men (315 cases), for a sex ratio (M/F) of 1.88. Risk factors for renal failure in COVID-19 were age ¡İ 65 years (ORa 2.42; CIa95% [1.17 - 4.95]; p = 0.016), anemia (ORa 2.49; CIa95% [1.21 - 5.26]; p = 0.015), moderate (ORa 13; CIa95% [2.30 - 2.44]; p = 0.017), severe (ORa 26.2; CIa95% [4.85 - 4.93]; p = 0.002) and critical (ORa 108; CIa95% [16.5 - 21.76]; p &lt; 0.001) severity stages at admission. <b>Conclusion</b>: Renal failure would therefore be related to the severity of COVID-19 and is the most formidable factor, conditioning the course of the disease and the patient¡¯s vital prognosis.
%K COVID-19
%K Renal Failure
%K Risk Factors
%K Togo
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=132291