%0 Journal Article
%T Steroids, Tri- and Meroterpenoids with a Quinone Structure—A Review
%A Maryam S. M. Aghaei
%A Thies Thiemann
%J International Journal of Organic Chemistry
%P 32-68
%@ 2161-4695
%D 2024
%I Scientific Research Publishing
%R 10.4236/ijoc.2024.141003
%X Terpenoids with quinoid structures are found as natural products. This includes steroidal quinones, quinones with a secosteroid structure and meroterpenoid quinones. Importantly, catechol estrogens as endogenous metabolites of estradiol and estrone are precursors of reactive quinones and semiquinones, which are thought to contribute to estrogen-induced carcinogenesis. On the other hand, a number of quinones that include substituted naphthoquinones and anthraquinones are highly cytotoxic and have been used in cancer treatment. This makes the structures interesting synthetic targets. The following is a review of important natural and synthetic terpenoid and steroid quinone hybrids.
%K Steroid
%K Secosteroid
%K Meroterpenoid
%K Triterpenoid
%K Quinone
%K Anti-Tumour Agent
%K Antibiotic
%K Natural Product
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=132254