%0 Journal Article
%T Intraductal Prostatic Carcinoma: Epidemiological and Anatomopathological Aspects in Dakar
%A Ibou Thiam
%A Fabrice Senghor
%A Omar Sow
%A Kor Ndiaye
%A Mohamed Moustapha Ch¨¦rif Dial
%J Open Journal of Pathology
%P 54-63
%@ 2164-6783
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojpathology.2024.142007
%X <strong>Introduction:</strong> Intraductal carcinoma is often associated with high-grade, high-stage adenocarcinoma. Its frequency is variable and it is considered a poor prognostic factor. In our context, when prostatic carcinoma is diagnosed, pathologists do not always report the presence of this anatomopathological entity. We therefore conducted a study to determine the epidemiological and anatomopathological profile of patients with this lesion in Dakar. <strong>Materials and Methods:</strong> This is a retrospective descriptive study covering a 1-year period from January to December 2022. It focused on cases of intraductal carcinoma diagnosed among prostatic carcinomas collected in the anatomopathology laboratories of H<span style=\"white-space:nowrap;\">&amp;#244;</span>pital G¨¦n¨¦ral Idrissa Pouye (HOGIP) and H<span style=\"white-space:nowrap;\">&amp;#244;</span>pital Militaire de Ouakam (HMO). It was based on archives of anatomopathological reports, blocks and slides. A total of 200 cases of prostatic carcinoma were collated and reviewed to identify those presenting with intraductal carcinoma according to the diagnostic criteria of Guo and Epstein. <strong>Results: </strong>87 cases of intraductal carcinoma were found, representing 43.5% of prostatic carcinomas. The mean age was 71 years. Patients in their seventh decade were the most represented, <em>i.e.</em> 42.5%. The majority of samples examined were biopsies (72.4%). The mean PSA level was 965.91 ng/ml, with extremes ranging from 0.03 to 10,000 ng/ml. Histologically, 96.5% of cases (N = 84) were invasive prostatic carcinoma. Gleason score 8 (4 + 4) was the most common, accounting for 42.53% (N = 37). On average, the study found four (04) foci of intraductal carcinoma per specimen, with extremes ranging from 1 to 30. Dense cribriform architecture accounted for 78.16%, loose cribriform for 11.5%, solid for 8.04% and micropapillary for 2.3%. Six cases (6.9%) showed foci of comedonecrosis. The vast majority of radical prostatectomies (87.5%) were classified as pT3. Node invasion and perineural sheathing were observed in 12.5% and 52.32% of cases respectively. <strong>Conclusion:</strong> Intraductal carcinoma is a poor prognostic factor that must be systematically reported in the anatomopathological report. In Senegal, it is often associated with advanced stage, high-grade carcinoma and high PSA levels.
%K Intraductal Carcinoma
%K Prostate
%K Pathological Anatomy
%K Senegal
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=132041