%0 Journal Article %T Introducing the n<sup>th</sup>-Order Features Adjoint Sensitivity Analysis Methodology for Nonlinear Systems (n<sup>th</sup>-FASAM-N): I. Mathematical Framework %A Dan Gabriel Cacuci %J American Journal of Computational Mathematics %P 11-42 %@ 2161-1211 %D 2024 %I Scientific Research Publishing %R 10.4236/ajcm.2024.141002 %X This work presents the ¡°nth-Order Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems¡± (abbreviated as ¡°nth-FASAM-N¡±), which will be shown to be the most efficient methodology for computing exact expressions of sensitivities, of any order, of model responses with respect to features of model parameters and, subsequently, with respect to the model¡¯s uncertain parameters, boundaries, and internal interfaces. The unparalleled efficiency and accuracy of the nth-FASAM-N methodology stems from the maximal reduction of the number of adjoint computations (which are considered to be ¡°large-scale¡± computations) for computing high-order sensitivities. When applying the nth-FASAM-N methodology to compute the second- and higher-order sensitivities, the number of large-scale computations is proportional to the number of ¡°model features¡± as opposed to being proportional to the number of model parameters (which are considerably more than the number of features).When a model has no ¡°feature¡± functions of parameters, but only comprises primary parameters, the nth-FASAM-N methodology becomes identical to the extant nth CASAM-N (¡°nth-Order Comprehensive Adjoint Sensitivity Analysis Methodology for Nonlinear Systems¡±) methodology. Both the nth-FASAM-N and the nth-CASAM-N methodologies are formulated in linearly increasing higher-dimensional Hilbert spaces as opposed to exponentially increasing parameter-dimensional spaces thus overcoming the curse of dimensionality in %K Computation of High-Order Sensitivities %K Sensitivities to Features of Model Parameters %K Sensitivities to Domain Boundaries %K Adjoint Sensitivity Systems %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=132058