%0 Journal Article
%T Tg与TgAb在甲状腺乳头状癌淋巴结转移中的研究进展<br>Research Progress of Tg and TgAb in Lymph Node Metastasis of Papillary Thyroid Carcinoma
%A 高月
%A 吴乃君
%A 马铭慧
%A 王琪
%J Advances in Clinical Medicine
%P 499-505
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/ACM.2024.143730
%X 甲状腺球蛋白在甲状腺滤泡上皮细胞中合成并分泌的，是甲状腺中表达量最高的蛋白。目前研究认为，术前血清甲状腺球蛋白可能与甲状腺乳头状癌颈淋巴结转移相关，然而其临床最佳临界值目前尚无统一标准；甲状腺球蛋白抗体作为针对甲状腺球蛋白产生的抗体，定性TgAb状态(阳性或阴性)决定了Tg化验的风险干扰。研究表明联合检测颈部超声、FNA-Tg可以提高其临床预测价值，帮助优化新诊断PTC患者的手术计划，减少再手术次数，改善预后。本文总结相关文献内容，介绍甲状腺球蛋白及甲状腺球蛋白抗体在甲状腺乳头状癌淋巴结转移中的研究进展，并进行综述。<br />
Thyroglobulin is synthesized and secreted by thyroid follicular epithelial cells and is the most high-ly expressed protein in the thyroid gland. Current studies suggest that preoperative serum thy-roglobulin may be associated with cervical lymph node metastasis in papillary thyroid carcinoma. However, there is no unified standard for the optimal clinical cut-off value. Thyroglobulin antibodies as antibodies produced against thyroglobulin, qualitative TgAb status (positive or negative) deter-mines the risk of interference in Tg assays. Studies have shown that combined detection of neck ul-trasound and FNA-Tg can increase its clinical predictive value, help to optimize the operation plan of newly diagnosed PTC patients, reduce the number of reoperation, and improve the prognosis. This article summarizes the relevant literature, introduces the research progress of thyroglobulin and thyroglobulin antibody in lymph node metastasis of papillary thyroid carcinoma, and reviews it.
%K 甲状腺乳头状癌，甲状腺球蛋白，淋巴结转移，甲状腺球蛋白抗体<br>Papillary Thyroid Carcinoma
%K Thyroglobulin
%K Lymph Node Metastasis
%K Anti-Thyroglobulin
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=82683