%0 Journal Article
%T Epidemiology of EGFR Mutation in Adenocarcinoma NSCLC Patients in India: A Systematic Review and Meta-Analysis
%A Ankita Jain
%A Kumar Prabhash
%A Venkatraman Radhakrishnan
%A Shashank Srinivasan
%J Advances in Lung Cancer
%P 1-21
%@ 2169-2726
%D 2024
%I Scientific Research Publishing
%R 10.4236/alc.2024.131001
%X Studies
reporting the Indian prevalence of Epidermal Growth Factor Recep</span><span style=\"font-family:Verdana;\">tor (EGFR) mutation</span></span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">are
mostly single center</span><span style=\"font-family:Verdana;\">s</span><span style=\"font-family:Verdana;\"> with small sample size</span><span style=\"font-family:Verdana;\">s</span><span style=\"font-family:Verdana;\">. Thi</span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">s </span><span style=\"font-family:Verdana;\">systematic review and meta-analysis
summarized the available evidence of</span> <span style=\"font-family:Verdana;\">EGFR
mutation epidemiology in Indian patients with adenocarcinoma</span><span style=\"font-family:Verdana;\"> (ADC) Non-Small
Cell Lung Cancer (NSCLC). We conducted a structured literature search in
PubMed, and EMBASE databases from January 2004 through October 2019.</span></span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">The primary outcome of
interest was prevalence of EGFR mutation</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">by gender, smoking status, and mutation subtype. The
review included 34 studies. EGFR mutation prevalence was 39.5% in patients with
ADC, and significantly higher in females, non-smokers, and patients with exon
19 deletions. The EGFR mutation frequency in Indian patients with ADC was
higher </span><span style=\"font-family:Verdana;\">than reported in Caucasians but at </span></span><span style=\"font-family:Verdana;\">a</span><span style=\"font-family:Verdana;\"> lower range of that reported in Eas</span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">t </span><span style=\"font-family:Verdana;\">Asians. These findings support the use of EGFR
mutation testing to guide</span><span style=\"font-family:Verdana;\"> choice of treatment.
%K Epidemiology
%K Epidermal Growth Factor Receptor
%K Adenocarcinoma
%K Non-Small Cell Lung Cancer
%K India
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=131741