%0 Journal Article
%T MTDH与骨肉瘤的相关研究进展<br>Research Progress in Correlation between MTDH and Osteosarcoma
%A 魏宇航
%A 薛飞
%A 冯卫
%J Advances in Clinical Medicine
%P 190-199
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/ACM.2024.143684
%X 骨肉瘤是青少年常见的原发性恶性肿瘤，以恶性程度高、预后差、5年生存率低为特点，对患者的生命健康造成严重威胁。如何有效改善骨肉瘤患者的预后，提高治愈率，已成为目前骨肉瘤治疗研究中的热点问题。在许多恶性肿瘤的研究中，异黏蛋白(MTDH)已被证实在肿瘤的发生发展中具有重要作用，参与肿瘤细胞的增殖、侵袭、转移及耐药过程。在骨肉瘤中MTDH基因的作用也得到了部分验证，可将其作为骨肉瘤治疗中的新靶点。本文主要综述了MTDH基因的最新研究现状及其在骨肉瘤中的作用的研究进展。<br />
Osteosarcoma is a common primary malignant tumor in adolescents, characterized by high malig-nancy, poor prognosis, and low 5-year survival rate, posing a serious threat to the life and health of patients. How to effectively improve the prognosis of patients with osteosarcoma and increase the cure rate has become a hot topic in current research on the treatment of osteosarcoma. In many studies of malignant tumors, it has been proven that metadherin (MTDH) plays an important role in the occurrence and development of tumors, participating in the proliferation, invasion, metastasis, and drug resistance processes of tumor cells. The role of MTDH gene in osteosarcoma has also been partially validated, and it can be used as a new target in the treatment of osteosarcoma. This article mainly reviews the latest research status of MTDH gene and its role in osteosarcoma.
%K 异黏蛋白，骨肉瘤，耐药<br>MTDH
%K Osteosarcoma
%K Drug Resistance
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=82394