%0 Journal Article
%T Correlation between DKK-1 Level and Bone Density Status in Children on Maintenance Haemodialysis
%A Manal Abd El-Salam
%A Marwa Mohamed Anwar
%A Rasha Mahmoud Gouda
%A Naglaa Abou El Fattah
%A Nadia Youssef Riad
%J Open Journal of Nephrology
%P 48-61
%@ 2164-2869
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojneph.2024.141006
%X <strong>Background:</strong> Renal osteodystrophy (ROD) is a bone disorder resulting from chronic kidney disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialysis (HD). <strong>Subjects and Methods:</strong> This case-control study involved 40 children with CKD on HD and 40 healthy children as controls. The study measured serum DKK-1 levels and performed a dual-energy X-ray absorptiometry scan (DEXA) in line with routine laboratory investigations. <strong>Results:</strong> There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively, with a p-value of less than 0.001. In the hemodialysis group, 25 patients (62.5%) had low bone mineral density (BMD) with a Z-score of under -2.0. Eighteen of these patients had low BMD in both the neck of the femur and lumbar spines. Additionally, there was a significant increase in serum DKK-1 level in patients with low BMD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BMD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. <strong>In conclusion</strong>, the study indicates a clear correlation between DKK-1 and BMD in children undergoing maintenance hemodialysis. DKK1 is a promising biomarker for CKD-MBD.
%K DKK-1
%K Children
%K Haemodialysis
%K Bone Density Status
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=131255