%0 Journal Article
%T The Effect of a Novel Complex, Composed of Ceramide, Energizing Peptide and Camu Camu Extract, on Epidermal Barrier Function and Dermal Antiaging Properties in <i>Ex Vivo</i> Human Skin Small Live Cohort
%A Landau Marina
%A Landau-Blum Shir
%A Samuel Kassirer
%A Audrey Le Mestr
%A Armelle Perrin
%A Julien Verdon
%A Laurine Bergeron
%A Corinne Morel
%A Isabelle Imbert
%J Journal of Cosmetics, Dermatological Sciences and Applications
%P 1-11
%@ 2161-4512
%D 2024
%I Scientific Research Publishing
%R 10.4236/jcdsa.2024.141001
%X <p>
	<span style=\"font-family:;\" \"=\"\">The
skin¡¯s primary function is to protect the body against a spectrum of
environmental stressors, including mechanical insults, microorganisms,
chemicals, and allergens. Located in the outermost layers, the primary
structures and components responsible for the skin¡¯s barrier function are
susceptible to environmental variables, dermatological conditions, and the
aging process. The ensuing alterations to structure, composition, and
organizational attributes of the epidermal barrier can impact its integrity and
functionality. The aim of this study was to assess the effect of a novel
complex composed of a ceramide, energizing peptide, and Camu Camu extract
(SUPCERAT<sup>TM</sup> complex) on specific markers of epidermal barrier
integrity, as well as epidermal and dermal function. All the experiments were
conducted on fresh human abdominal skin explants. Intradermal production of
hyaluronic acid, epidermal claudin-1, and ceramide synthase 3 expressions, as
well as epidermal lipids content were assessed using specific fluorescent
stainings on <i>ex vivo </i>skin after the
application of the complex or placebo. Additionally, dermal elastase and
collagenase activities were assessed using <i>in
tubo</i> enzymatic ass<span>ays. Lastly, the
effect of a cosmetic cream containing SUPCERAT<sup>TM</sup> complex wa</span><span>s assessed using subjective Global Aesthetic
Improvement Scale (GAIS) in a</span><span> small
cohort of patients after 60 days of use. The application of the SUPCERAT<sup>TM</sup> co</span>mplex on <i>ex vivo </i>skin led to
significant increase in dermal hyaluronic acid content and epidermal activity
of claudin-1, ceramide synthase 3 and epidermal ceramide content. Furthermore, <i>in tubo</i> enzymatic assays demonstrated
inhibition of both dermal elastase and collagenase activities. In addition, the
patient-reported results indicated significant improvements in skin quality and
appearance.</span><span style=\"font-family:;\" \"=\"\"></span> 
</p>
%K SUPCERATTM Complex
%K Epidermal Skin Barrier
%K Moisturization
%K Antiaging
%K Ceramide
%K Camu Camu Extract
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=131269