%0 Journal Article
%T Sickle Cell Disease in the Zinder Region in 2023: Prevalence and Sociodemographic Factors
%A Brah Moustapha Maman
%A Amadou Djibrilla-Almoustapha
%A Moustapha Elhadji-Chefou
%A Illa Hamidine
%A Moussa Diongol¨¦ Hassane
%A Bad¨¦ Malam-Abdou
%J Open Journal of Blood Diseases
%P 1-7
%@ 2164-3199
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojbd.2024.141001
%X <strong>Introduction:</strong> <span style=\"font-family:;\" \"=\"\">In view of the number of sickle cell patients and due to a low production
of descriptive studies, we decided to determine the prevalence of genes S and C
of the disease in the Zinder region. The objective was to contribute to
improving the management of sickle cell disease in Zinder. <b>Methodology: </b>This
was a systematic screening by the ˇ°Sickle Scanˇ± test of any blood donor
admitted to the Zinder Regional Blood Transfusion Center during the 6-month
study period, from January to June 2023. The Sickle Scan is a qualitative
lateral flow chromatography immunoassay using whole blood samples that aid in
the rapid diagnosis of sickle cell disease. <b>Results:</b> The study was
carried out on 613 samples during the period concerned. The frequency of sickle
cell genes was 26.9% (n = 165) in all samples collected, with 23.1% (n = 142)
and 3.8% (n = 23) for the S gene and the C gene, respectively. The 18</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\">-</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\">30 age group was the most represented with 64.4% (n
= 395) cases. The median age of blood donors was 26 years ˇŔ 10 years (min = 18
years/max = 60 years). The sex ratio was 2.5. Donors of Nigerien nationality
accounted for 84.1% (n = 516). There is a predominance of blood donors with an
average monthly income between 34</span><span style=\"font-family:;\" \"=\"\">,</span><span style=\"font-family:;\" \"=\"\">000 and 70</span><span style=\"font-family:;\" \"=\"\">,</span><span style=\"font-family:;\" \"=\"\">000 CFA
francs in 44.3% (n = 272), lived in permanent housing with drinking water
supply. Sickle cell trait (SMA) was found in 22.5% (n = 138). <b>Conclusion:</b> The analysis of these results highlights a high frequency of the S gene for
sickle cell disease. The population with an average monthly income is the most
affected, with a male predominance.</span>
%K Sickle Cell Anemia
%K Blood Donors
%K Sickle Scan
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=131013