%0 Journal Article
%T 冠周脂肪衰减指数与PCI术后再狭窄<br>Perivascular Adipose Tissue CT Fat Attenuation Index for Coronary In-Stent Restenosis
%A 刘强
%J Advances in Clinical Medicine
%P 1991-1995
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/ACM.2024.141280
%X 血管炎症被认为是导致动脉粥样硬化斑块形成和不稳定的主要因素。近年来大型前瞻性队列研究表明，冠状动脉周围脂肪(PCAT)的CT衰减指数是冠状动脉炎症的敏感和动态生物标志物，且是长期不良心脏事件的有力且独立的预测因子。PCI术后再狭窄是局部血管损伤后的一种修复反应，其中炎性细胞导致血管损伤后平滑肌细胞分裂增殖能力增强，合成大量的细胞外基质，是再狭窄的主要病理机制。本综述讨论了PCAT的病理生理特点与PCI术后再狭窄机制的可能相关性及冠周脂肪衰减指数在改善心血管危险分层的发展前景，为广大研究者提供一篇系统、全面的冠周脂肪衰减指数与PCI术后再狭窄的综述。<br />
Vascular inflammation is thought to be leading to atherosclerosis plaque formation and the main factors of instability. In recent years, large prospective cohort studies have shown that the CT at-tenuation index of pericoronary fat (PCAT) is a sensitive and dynamic biomarker of coronary in-flammation, and is a strong and independent predictor of long-term adverse cardiac events. Local after vascular injury of PCI postoperative restenosis is a repair response, including inflammatory cells lead to smooth muscle cell proliferation after vascular injury, synthesis of a large amount of extracellular matrix, is the main pathological mechanism of restenosis. This review discusses the possible correlation between the pathophysiological characteristics of PCAT and the mechanism of restenosis after PCI, and the development prospect of pericoronidal fat attenuation index in improving cardiovascular risk stratification, so as to provide a systematic and comprehensive re-view of pericoronidal fat attenuation index and restenosis after PCI for researchers.
%K 冠状动脉周围脂肪，脂肪衰减指数，PCI术后再狭窄<br>Pericoronary Adipose Tissue (PCAT)
%K Fat Attenuation Index
%K In-Stent Restenosis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=80187