%0 Journal Article
%T 冠心病合并OSAHS患者CACS与AHI、LaSO<sub>2</sub>的相关性分析<br>Correlation Analysis of CACS and AHI, LaSO<sub>2</sub> in Patients with Coronary Heart Disease and OSAHS
%A 李娇
%A 孙建秀
%A 高娟
%A 曹丽华
%A 张文忠
%J Advances in Clinical Medicine
%P 1323-1330
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/ACM.2024.141191
%X 目的：探讨冠心病合并OSAHS患者的CACS与AHI、LaSO<sub>2</sub>之间的相关性。方法：回顾性收集2022年04月~2023年02月在青岛大学附属医院行PSG + CCTA的病例共114例。根据CCTA测得的CACS积分的情况，将患者分为无心血管病风险组：CACS = 0分(n = 49例)，有心血管病风险组：CACS &gt; 0分(n = 65例)。比较两组间相关指标的差异性，并明确CACS与AHI、LaSO<sub>2</sub>之间的相关及回归关系。结果：与无心血管风险组相比，有心血管风险组年龄、AHI更高，LaSO<sub>2</sub>更低，差异有统计学意义(p &lt; 0.05)。CACS总值与AHI呈显著的正相关(rs = 0.442, p &lt; 0.001)，与LaSO2呈显著的负相关(r<sub>s</sub> = ？0.378, p &lt; 0.001)。一元线性回归分析示：AHI、LaSO<sub>2</sub>是CACS的主要危险因素(B值分别为7.352，？5.936，β值分别为0.283、？0.133，p值分别为0.002、0.038)。在控制协变量后，AHI、LaSO2对CACS的效应仍显著(B值分别为9.653，？7.674，β值分别为0.371、？0.172，p值分别为0.014、0.045)，可作为CSCS的独立预测因子。结论：阻塞性睡眠呼吸暂停严重程度与CACS严重程度呈正相关，且AHI与CACS呈正相关，LaSO<sub>2</sub>与CACS呈负相关，AHI、LaSO<sub>2</sub>可被视为冠状动脉疾病高风险的独立预测因子(基于CACS)。<br />
Purpose: To investigate the correlation between CACS and AHI, LaSO<sub>2</sub> in patients with CHD com-bined with OSAHS. Methods: This study was a retrospective case analysis. 114 patients who under-went PSG + CCTA in the Affiliated Hospital of Qingdao University from April 2022 to April 2023 were collected. According to the CACS measured by CCTA, the patients were divided into two groups: the group without cardiovascular risk: CACS = 0 (n = 49 cases), and the group with cardiovascular risk: CACS &gt; 0 (n = 65 cases). The differences of relevant indexes in different groups were compared. And the correlation and regression relationship between CACS and AHI, LaSO<sub>2</sub> were clarified. Results: Compared with the group without cardiovascular risk, the group with cardiovascular risk had high-er age, AHI and lower LaSO<sub>2</sub>, and the difference was statistically significant (p &lt; 0.05). The CACS was significantly positively correlated with AHI (rs = 0.442, p &lt; 0.001) and negatively correlated with LaSO<sub>2</sub> (rs = ？0.378, p &lt; 0.001). Unary linear regression analysis showed that AHI and LaSO<sub>2</sub> were the main risk factors of CACS (B = 7.352, ？5.936, β = 0.283, ？0.133, p = 0.002, 0.038). After controlling for covariables, AHI and LaSO<sub>2</sub> still had significant effects on CACS (B = 9.653, ？7.674, β = 0.371, ？0.172, p = 0.014, 0.045), and were independent risk factors for CACS. Conclusions: The severity of OSAHS was positively correlated with the severity of CACS. AHI was positively correlated with CACS and LaSO<sub>2</sub> was negatively correlated with CACS, which could be considered as independent predic-tors of high risk of coronary artery disease (based on CACS).
%K 阻塞性睡眠呼吸暂停，低通气综合征，冠心病，冠脉钙化积分<br>OSA
%K OSAHS
%K Coronary Heart Disease
%K Coronary Artery Calcification Score
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=79830