%0 Journal Article
%T A Potential Role for GLUT4 in Predicting Sepsis in Critically Ill Children
%A Yanna Zhou
%A Guangming Liu
%A Xiaohui Wu
%A Aidi Kuang
%A Cuiping Zhu#
%A Qiuyan Peng#
%J Open Journal of Internal Medicine
%P 1-15
%@ 2162-5980
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojim.2024.141001
%X <strong>Background:</strong> This study investigated serum Glucose transporter (GLUT) 4 levels and examined the relationship between serum GLUT4 levels and sepsis in critically ill children. <strong>Methods:</strong> This was a retrospective study of 77 critically ill children and 33 non-diabetic healthy children (controls) who were admitted between 07/2015 and 05/2016. Patient data, clinical information, and blood samples were collected on admission, alongside a large number of laboratory parameters that were routinely assessed. Critically ill patients were divided into sepsis and non-sepsis/systemic inflammatory response syndrome (SIRS). Serum GLUT4 was measured using western blotting and enzyme-linked immunosorbent assays. Insulin resistance indexes, clinical data, laboratory parameters, and inflammatory cytokines were assessed. <strong>Results:</strong> GLUT4 serum levels were higher in critically ill children than in healthy children (90.5 vs. 30.3 ¦Ìg/L, P &lt; 0.001), and in septic shock compared with sepsis (116.8 vs. 64.3 ¦Ìg/L, P &lt; 0.05), but not compared to non-sepsis/systemic inflammatory response syndrome (105.7 ¦Ìg/L, P &gt; 0.05). Compared to healthy children, hyperglycemic patients (n = 48) had elevated GLUT4 serum levels (30.3 vs. 103.7 g/L, P &lt; 0.001). Serum GLUT4 levels were higher in patients who died (n = 16, P &lt; 0.05) than in those who survived (n = 57). Serum GLUT4 levels were positively correlated with the neutrophil count, creatine kinase levels, and glucose levels (P &lt; 0.05). GLUT4 levels for the diagnosis of sepsis had an area under the curve of 0.70 (P = 0.03) when using a 51-¦Ìg/L cut-off value, resulting in 74.6% sensitivity and 80% specificity. <strong>Conclusions:</strong> GLUT4 serum levels might be significantly increased in critically ill children compared with healthy children, particularly those in septic shock. Serum GLUT4 could predict disease severity.
%K Children
%K Critical Illness
%K Glucose Transporter Type 4
%K Hyperglycemia
%K Insulin Resistance
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=130733