%0 Journal Article
%T 集落刺激因子联合放疗对抗肿瘤免疫调节的相关研究进展<br>Research Progress on Colony-Stimulating Factor Combined with Radiotherapy to Fight Tumor Immunomodulation
%A 张峻
%A 王兰
%A 王琪
%A 郭天慧
%A 王海冀
%J Advances in Clinical Medicine
%P 1202-1209
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/ACM.2024.141174
%X 集落刺激因子(Colony-stimulating factor, CSF)是一种细胞因子，可以预防或治疗化学治疗引起的中性粒细胞减少，主要用于接受化疗或接受高度血液毒性治疗方案的患者。随着现代放射治疗技术和支持治疗的发展，放化疗与集落刺激因子的联合治疗值得被重新评估。放射治疗在体内和体外均可诱导免疫系统介导的抗癌全身效应。这种效果在联合CSF的创新放射治疗模式的临床前和临床试验中得到了加强。到目前为止，放疗与CSF的联合效应尚未与免疫疗法相结合。然而，它可能在引发针对癌细胞的免疫应答中起主要作用，进而诱导远隔效应。本文通过对集落刺激因子、放疗和免疫治疗联合疗法的有效性,以及放疗联合集落刺激因子对抗肿瘤免疫调节方面的最新研究进行综述，进一步评估集落刺激因子与放疗及免疫治疗联用的可行性。<br />
Colony-stimulating factor (CSF) is a cytokine that can prevent or treat chemotherapy-induced neu-tropenia, primarily in patients receiving chemotherapy or receiving highly hematotoxic treatment regimens. With the development of modern radiotherapy techniques and supportive care, the com-bination of chemoradiotherapy and colony-stimulating factor deserves to be re-evaluated. Radiation therapy can induce systemic effects mediated by the immune system against cancer both in vivo and in vitro. This effect is reinforced in preclinical and clinical trials of an innovative radiotherapy modality in combination with CSF. So far, the combined effect of radiotherapy with CSF has not been combined with immunotherapy. However, it may play a major role in eliciting an immune response against cancer cells, which in turn induces the distancing effect. This article reviews the effective-ness of the combination of colony-stimulating factor, radiotherapy and immunotherapy, as well as the latest research on the immunomodulation of radiotherapy combined with colony-stimulating factor against tumors, and further evaluates the feasibility of combining colony-stimulating factors with radiotherapy and immunotherapy.
%K 放射治疗，集落刺激因子，免疫治疗，肿瘤<br>Radiation Therapy
%K Colony-Stimulating Factor
%K Immunotherapy
%K Tumors
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=79740