%0 Journal Article
%T 68Ga-FAPI在乳腺癌诊断中的研究进展<br>Research Progress of 68Ga-FAPI in the Diagnosis of Breast Cancer
%A 邓贵斌
%A 李义兴
%A 沈小兰
%A 刘德慧
%J World Journal of Cancer Research
%P 20-26
%@ 2164-9057
%D 2024
%I Hans Publishing
%R 10.12677/WJCR.2024.141004
%X 乳腺癌(Breast cancer, BC)是女性最常见的恶性肿瘤，又称为“粉红杀手”，在癌症相关妇女死亡原因中排第二。成纤维细胞活化蛋白(fibroblast activation protein, FAP)，高度表达于肿瘤相关成纤维细胞中，近年来，基于喹啉设计的小分子FAP抑制剂(FAP inhibitor, FAPI)显示出优秀的FAP亲和力，在乳腺癌中摄取量较高。随着技术的发展，68Ga标记的FAPI在乳腺癌的诊断中得到了进一步的发展。本文就近年来68Ga-FAPI在乳腺癌中的临床研究和应用进展做简要综述，以提高其临床应用效益。<br />
Breast cancer (BC) is the most common malignancy in women, also known as the “Pink Killer”. BC is the second leading cause of cancer-related death in women. Fibroblast activation protein (FAP) is highly expressed in tumor-associated fibroblasts. Recently, small molecule FAP inhibitor (FAPI) based on quinoline design has shown an excellent affinity for FAP, high intake in breast cancer. With the development of technology, 68Ga-labeled FAPI (68Ga-FAPI) has been further developed in the diagnosis of breast cancer. In this review, the clinical research and application of 68Ga-FAPI in breast cancer were reviewed to improve the clinical benefit.
%K 成纤维细胞活化蛋白抑制剂，乳腺癌，正电子发射计算机断层显像<br>Fibroblast Activating Protein Inhibitor
%K Breast Cancer
%K PET/CT
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=79404