%0 Journal Article
%T Cancer Occurrence and Associated Factors to Malignancy in BIRADS-3 Lesions in Yaoundé: The Need to Be More Proactive for Patients above 40, Non-Compliant with Imaging Follow-Up and Presenting with Nipple Discharge
%A Joseph-Francis Nwatsock
%A Ambroise Merci Seme-Engoumou
%A Coralie Reine Bertine Mendouga-Menye
%A Etienne Atenguena-Okobalemba
%A Lionel Tabola
%A Boniface Moifo
%J Open Journal of Medical Imaging
%P 127-135
%@ 2164-2796
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojmi.2023.134013
%X Background and objectives: Breast Imaging Reporting and Data System in Category 3 (BIRADS-3) includes probably benign lesions which need a short-term imaging follow-up. However, in our context, the lesions graded BIRADS-3 remain insufficiently evaluated. We therefore conducted this study to assess the cancer occurrence and associated factors in BIRADS-3 lesions during the follow-up in order to propose an adaptation of the management for lesions in this category in our setting. Patients and methods: A retrospective longitudinal study of patients with lesions initially classified as BIRADS-3 and who realised each at least one additional imaging check-up between January 2014 and December 2022 in five Yaound¨¦ hospitals. All clinical and imaging data were analysed using SPSS® 21.0 software with a significant p-value < 0.05. Results: Patients were aged 13 to 73 (33.0 ¡À 13.4) years, with a history of breast mass (315 cases; 79.7%), breast pain (25 patients; 6.3%), nipple discharge (20 patients; 5.1%) or past family history of breast cancer (25 cases; 6.3%). The most common baseline abnormalities were mammogram opacities (64.8%) and microcalcifications (48.6%), whereas initial breast ultrasound showed solid masses (77.0%) and cystic lesions (11.1%). Compliance with imaging appointment periods was low with only 23.9% of all patients performing an imaging control at the scheduled moment. During the follow-up, 115 patients (29.1%) were upgraded to BIRADS-4 and histology performed revealed 43 cancers (10.9% of overall initial BIRADS-3 sample). The presence of malignancies was associated to age above 40 years (p = 0.0001) and to the presence of nipple discharge (p = 0.0375). Conclusion: The frequency of malignancies among initial BIRADS-3 lesions in our series is higher than that described in the guidelines. This study highlights the need to be more proactive in the management of BIRADS-3 lesions in our setting as the compliance with follow-up is low. So, biopsy should be considered as an alternative to long-term follow-up for patients above 40, non-compliant with imaging check-ups and presenting with nipple discharge.
%K BIRADS-3
%K Cancer Occurrence
%K Associated Factors to Malignancy
%K Imaging Follow-Up
%K Yaoundé
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=130246